Accession | ARO:3002384 |
Definition | BEL beta-lactamases are class A expanded-spectrum beta-lactamases that are inhibited by clavulanic acid. They are chromosomally encoded and hydrolyze most cephalosporins and aztreonam. |
Drug Class | penam, monobactam, cephalosporin |
Resistance Mechanism | antibiotic inactivation |
Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + antibiotic inactivation enzyme + cephem + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase |
Parent Term(s) | 4 ontology terms | Show + class A beta-lactamase + confers_resistance_to_drug_class penam [Drug Class] + confers_resistance_to_drug_class monobactam [Drug Class] + confers_resistance_to_drug_class cephalosporin [Drug Class] |
Sub-Term(s) | 4 ontology terms | Show |
Publications | Poirel L, et al. 2005. Antimicrob Agents Chemother 49(9): 3743-3748. BEL-1, a novel clavulanic acid-inhibited extended-spectrum beta-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa. (PMID 16127048) |