OXY beta-lactamase [AMR Gene Family]

Accession ARO:3002388
Synonym(s)KOXY K1
DefinitionOXY beta-lactamases are chromosomal class A beta-lactamases that are found in Klebsiella oxytoca. At constitutive low levels, OXY beta-lactamases confer resistance to aminopenicillins and carboxypenicillins. At high induced levels, OXY beta-lactamases confer resistance to penicillins, cephalosporins and aztreonam.
Drug Classmonobactam, cephalosporin, penam
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_drug_class monobactam [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ class A beta-lactamase
Sub-Term(s)
26 ontology terms | Show
Publications

Liang YH, et al. 2012. Acta Crystallogr D Biol Crystallogr 68(PT 11): 1460-1467. Structural insights into the broadened substrate profile of the extended-spectrum beta-lactamase OXY-1-1 from Klebsiella oxytoca. (PMID 23090395)