OXY-1-4

Accession ARO:3002392
CARD Short NameOXY-1-4
DefinitionOXY-1-4 is a beta-lactamase found in Klebsiella oxytoca.
AMR Gene FamilyOXY beta-lactamase
Drug Classmonobactam, penam, cephalosporin
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesKlebsiella michiganensisg+wgs
Resistomes with Sequence VariantsKlebsiella michiganensisg+wgs, Klebsiella oxytocag
Classification15 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ OXY beta-lactamase [AMR Gene Family]
Publications

Granier SA, et al. 2003. Int J Syst Evol Microbiol 53(PT 3): 661-668. Recognition of two genetic groups in the Klebsiella oxytoca taxon on the basis of chromosomal beta-lactamase and housekeeping gene sequences as well as ERIC-1 R PCR typing. (PMID 12807183)

Resistomes

Prevalence of OXY-1-4 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Klebsiella michiganensis12.9%0%9.57%0%
Klebsiella oxytoca2.56%0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|AAL78276.1|+|OXY-1-4 [Klebsiella oxytoca]
MLKSSWRKTALMAAAVPLLLASGSLWASADAIQQKLADLEKRSGGRLGVALINTADDSQTLYRGDERFAMCSTGKVMAAAAVLKQSESNP
EVVNKRLEIKKSDLVVWSPITEKHLQSGMTLAELSAAALQYSDNTAMNKMISYLGGPEKVTAFAQSIGDVTFRLDRTEPALNSAIPGDKR
DTTTPLAMAESLRKLTLGNALGEQQRAQLVTWLKGNTTGGQSIRAGLPASWVVGDKTGAGDYGTTNDIAVIWPENHAPLVLVTYFTQPQQ
DAKSRKEVLAAAAKIVTEGL


>gb|AY077483.1|+|183-1055|OXY-1-4 [Klebsiella oxytoca]
ATGTTGAAAAGTTCGTGGCGTAAAACCGCCCTGATGGCCGCCGCCGTTCCGCTGCTGCTGGCGAGCGGTTCATTATGGGCCAGTGCCGAT
GCTATCCAGCAAAAGCTGGCTGATTTAGAAAAACGTTCCGGCGGTCGGCTGGGCGTAGCGCTGATTAACACGGCAGATGATTCGCAAACC
CTCTATCGCGGCGATGAACGTTTTGCCATGTGCAGCACCGGTAAAGTGATGGCCGCCGCCGCGGTGTTAAAACAGAGCGAAAGCAATCCA
GAGGTGGTGAATAAAAGGCTGGAGATTAAAAAATCGGATTTAGTGGTCTGGAGCCCGATCACCGAAAAACATCTGCAAAGCGGAATGACC
CTGGCGGAACTCAGCGCGGCGGCGCTGCAGTACAGCGACAATACCGCGATGAATAAGATGATTAGCTACCTTGGCGGACCGGAAAAGGTG
ACCGCATTCGCCCAGAGTATCGGGGATGTCACTTTTCGTCTCGATCGTACGGAGCCGGCGCTGAACAGCGCGATTCCCGGCGATAAGCGC
GATACCACCACCCCGTTGGCGATGGCCGAAAGCCTGCGCAAGCTGACGCTGGGCAATGCGCTGGGCGAACAGCAGCGCGCCCAGTTAGTG
ACGTGGCTAAAAGGCAATACCACCGGCGGGCAAAGCATTCGCGCAGGCCTGCCCGCAAGCTGGGTGGTCGGGGATAAAACCGGCGCCGGA
GATTACGGCACCACCAACGATATCGCGGTGATCTGGCCGGAAAATCATGCCCCGCTGGTGCTGGTGACCTATTTTACCCAGCCGCAGCAG
GATGCGAAAAGCCGCAAAGAGGTGTTAGCCGCGGCGGCAAAAATCGTCACCGAAGGGCTTTAA