MuxB

Accession ARO:3004074
Synonym(s)PA2527
CARD Short NameMuxB
DefinitionMuxB is one of the two necessary RND components in the Pseudomonas aeruginosa efflux pump system MuxABC-OpmB.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classaminocoumarin antibiotic, tetracycline antibiotic, monobactam, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesPseudomonas aeruginosag+p+wgs, Pseudomonas fluorescensg
Resistomes with Sequence VariantsPseudomonas aeruginosag+p+wgs, Pseudomonas fluorescensg
Classification18 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Mima T, et al. 2009. Microbiology (Reading, Engl.) 155(Pt 11):3509-17 Gene cloning and characteristics of the RND-type multidrug efflux pump MuxABC-OpmB possessing two RND components in Pseudomonas aeruginosa. (PMID 19713238)

Resistomes

Prevalence of MuxB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Pseudomonas aeruginosa99.23%0.29%65.91%0%
Pseudomonas fluorescens2.78%0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1900


>gb|AAG05915.1|-|MuxB [Pseudomonas aeruginosa PAO1]
MNPSRPFILRPVATTLLMVAILLSGLIAYRFLPISALPEVDYPTIQVVTLYPGASPEIMTSSITAPLENQLGQIPGLNEMSSSSSGGASV
ITLQFSLQSNLDVAEQEVQAAINAAQSLLPNDLPNQPVFSKVNPADAPILTLAVMSDGMPLPQIQDLVDTRLAQKISQISGVGLVSISGG
QRPAVRVRANPTALAAAGLSLEDLRSTVTSNNLNGPKGSFDGPTRASTLDANDQLRSADAYRDLIIAYKNGSPLRIRDVASVEDDAENVR
LAAWANNLPAVVLNIQRQPGANVIEVVDRIKALLPQLQSTLPGNLDVQVLTDRTTTIRASVKDVQFELALAVALVVMVTFLFLRNVYATL
IPSFAVPLSLIGTFGVMYLSGFSINNLTLMALTIATGFVVDDAIVMVENIARYLEQGDSPLEAALKGSKQIGFTIISLTFSLIAVLIPLL
FMGDVAGRLFREFAITLAVAILISGFVSLTLTPMLSAKLLRHIDEDQQGRFARAAGRVIDGLIAQYAKALRVVLRHQPLTLLVAIATLAL
TALLYLAMPKGFFPVQDTGVIQGVAEAPQSISFQAMSERQRALAEVVLKDPAVASLSSYIGVDGSNPTLNTGRLLINLKPHSERDVTASE
VIQRLQPELDHLPGIKLYMQPVQDLTIEDRVARTQYQFTLQDADPDVLAEWVPKLVARLQELPQLADVASDWQDKGLQAYLNIDRDTASR
LGVKLSDIDSVLYNAFGQRLISTIFTQATQYRVVLEVAPQFQLGPQALEQLYVPSSDGTQVRLSSLAKVEERHTLLAINHIAQFPSATLS
FNLAKGYSLGEAVEAIRGVEASLELPLSMQGSFRGAALAFEASLSNTLLLILASVVTMYIVLGILYESFIHPVTILSTLPSAGVGALLAL
MLAGQEIGIVAIIGIILLIGIVKKNAIMMIDFALDAERNEGKPPHEAIYQACLLRFRPILMTTMAALLGALPLMLAGGAGAELRQPLGIT
MVGGLLLSQVLTLFTTPVIYLYFDRLARRWAAWRKQRGLDLNTEAGFDGDAGR


>gb|AE004091.2|-|2850883-2854014|MuxB [Pseudomonas aeruginosa PAO1]
ATGAACCCGTCCCGCCCGTTCATCCTGCGGCCGGTCGCGACCACCCTGCTGATGGTGGCGATCCTGCTCTCGGGCCTGATCGCCTACCGC
TTCCTGCCGATCTCGGCGTTGCCGGAAGTGGACTACCCGACCATCCAGGTGGTCACCCTGTACCCCGGCGCCAGCCCGGAGATCATGACC
TCGTCGATCACCGCGCCGCTGGAGAACCAGCTCGGGCAGATTCCGGGGCTCAACGAGATGTCTTCCAGCAGTTCCGGCGGCGCCTCGGTG
ATCACCCTGCAATTCAGCCTGCAGAGCAACCTCGATGTCGCCGAGCAGGAAGTCCAGGCGGCGATCAACGCCGCGCAGAGCCTGCTGCCC
AACGACCTGCCGAACCAGCCGGTGTTCAGCAAGGTGAATCCGGCGGACGCACCGATCCTGACCCTGGCGGTGATGTCCGACGGCATGCCG
CTGCCGCAGATCCAGGACCTGGTGGATACCCGCCTGGCACAGAAGATCTCGCAGATCTCCGGGGTCGGCCTGGTCAGCATCAGCGGCGGC
CAGCGCCCGGCGGTGCGGGTGCGCGCCAACCCGACGGCGCTGGCGGCGGCGGGGCTGAGCCTGGAGGACCTGCGCAGCACGGTGACCAGC
AACAACCTCAACGGCCCCAAGGGCAGCTTCGACGGCCCGACCCGTGCCTCGACCCTGGACGCCAACGACCAGTTGCGCTCGGCCGACGCC
TACCGCGACCTGATCATCGCCTACAAGAACGGCTCGCCGCTGCGCATCCGCGACGTCGCCAGCGTCGAGGACGACGCCGAGAACGTGCGC
CTGGCCGCCTGGGCCAACAACCTGCCGGCGGTGGTGCTGAACATCCAGCGCCAGCCGGGGGCCAACGTGATCGAGGTGGTCGACCGGATC
AAGGCGCTGCTGCCGCAGCTGCAATCGACCCTGCCGGGCAATCTCGACGTGCAGGTGCTGACCGACCGCACCACCACCATCCGCGCCTCG
GTCAAGGACGTGCAGTTCGAGCTGGCGCTGGCGGTGGCGCTGGTGGTGATGGTCACCTTCCTGTTCCTGCGCAACGTCTACGCCACCCTG
ATTCCCAGCTTCGCCGTGCCGCTGTCGCTGATCGGTACCTTCGGCGTGATGTACCTGTCCGGCTTCTCGATCAACAACCTGACCCTGATG
GCGCTGACCATCGCCACCGGCTTCGTGGTCGACGACGCGATCGTCATGGTGGAGAACATCGCCCGCTACCTGGAGCAGGGCGACTCGCCG
CTGGAAGCGGCGCTCAAGGGCTCGAAGCAGATCGGCTTCACCATCATCTCGCTGACTTTCTCGCTGATCGCCGTGCTGATCCCGCTGCTG
TTCATGGGCGACGTCGCCGGGCGGCTGTTCCGCGAGTTCGCCATCACCCTGGCGGTGGCGATCCTGATTTCCGGCTTCGTCTCCCTGACC
CTTACGCCGATGCTCAGCGCCAAGCTGCTGCGCCACATCGACGAGGACCAGCAGGGCCGCTTCGCGCGCGCCGCGGGGCGGGTCATCGAT
GGCCTGATCGCACAGTACGCCAAGGCCCTGCGGGTGGTCCTGCGGCACCAGCCGCTGACCCTGCTGGTGGCCATCGCCACCCTGGCGCTG
ACCGCGCTACTCTACCTGGCCATGCCCAAGGGCTTCTTCCCGGTGCAGGACACCGGGGTGATCCAGGGCGTCGCCGAAGCGCCGCAGTCG
ATCTCCTTCCAGGCCATGTCCGAGCGCCAGCGCGCCCTTGCCGAGGTGGTGCTGAAGGACCCGGCGGTGGCCAGCCTGTCCTCCTACATC
GGCGTCGACGGCAGCAACCCGACCCTCAACACCGGCCGCCTGCTGATCAACCTCAAGCCGCACAGCGAGCGCGACGTCACCGCCAGCGAA
GTGATCCAGCGCCTGCAGCCCGAACTCGACCACCTGCCCGGGATCAAGCTGTACATGCAGCCGGTGCAGGACCTGACCATCGAGGACCGG
GTCGCCCGCACCCAGTACCAGTTCACCTTGCAGGACGCCGACCCGGACGTGCTCGCCGAGTGGGTGCCGAAGCTGGTGGCGCGGCTGCAG
GAGTTGCCGCAGCTCGCCGACGTCGCCAGCGACTGGCAGGACAAGGGCTTGCAGGCCTACCTGAACATCGACCGCGACACCGCCTCGCGC
CTCGGCGTGAAGCTCTCCGACATCGACAGCGTGCTCTACAACGCCTTCGGCCAGCGGCTGATCTCGACCATCTTCACCCAGGCCACCCAG
TACCGCGTGGTGCTGGAGGTGGCGCCGCAGTTCCAGCTCGGCCCGCAGGCCCTGGAGCAGCTCTACGTGCCGTCCAGCGACGGCACCCAG
GTGCGCCTGTCGAGCCTGGCGAAGGTGGAGGAGCGGCATACCCTGCTGGCGATCAACCATATCGCCCAGTTCCCCTCGGCGACCCTGTCG
TTCAACCTGGCCAAGGGTTACTCCCTGGGCGAGGCGGTCGAGGCGATCCGTGGCGTCGAGGCCAGCCTGGAGCTGCCGCTGAGCATGCAG
GGCAGCTTCCGCGGCGCGGCGCTGGCCTTCGAGGCCTCGCTGTCGAACACGCTGCTGCTGATCCTCGCCTCGGTGGTGACCATGTACATC
GTCCTGGGCATCCTCTACGAGAGCTTCATCCATCCGGTGACCATCCTCTCGACCCTGCCCTCGGCCGGGGTCGGCGCGCTGCTGGCGCTG
ATGCTGGCGGGGCAGGAGATCGGCATCGTGGCGATCATCGGCATCATCCTGCTGATCGGCATCGTCAAGAAGAACGCGATCATGATGATC
GATTTCGCCCTCGACGCCGAGCGCAACGAAGGCAAGCCGCCCCATGAGGCGATCTACCAGGCCTGCCTGCTGCGCTTCCGGCCGATCCTG
ATGACCACCATGGCCGCGCTGCTCGGCGCGCTGCCGCTGATGCTCGCCGGCGGCGCCGGCGCCGAGCTGCGCCAGCCGCTGGGCATCACC
ATGGTCGGTGGCCTGCTGCTGAGCCAGGTCCTGACCCTGTTCACCACCCCGGTGATCTATCTCTACTTCGACCGCCTGGCCCGTCGCTGG
GCGGCCTGGCGCAAGCAGCGCGGGCTGGACCTGAACACCGAGGCCGGGTTCGACGGGGACGCCGGGCGATGA