| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3000150 |
| Synonym(s) | Notomycin A1 |
| Definition | Coumermycin A1 is an antibiotic produced by Streptomyces rishiriensis, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. |
| SMILES | CO[C@H]1[C@H](OC(=O)c2ccc(C)[nH]2)[C@H](O)[C@@H](Oc2ccc3c(O)c(NC(=O)c4c[nH]c(C(=O)Nc5c(O)c6ccc(O[C@H]7OC(C)(C)[C@@H](OC)[C@H](OC(=O)c8ccc(C)[nH]8)[C@@H]7O)c(C)c6oc5=O)c4C)c(=O)oc3c2C)OC1(C)C |
| PubChem | 54675768 |
| ChEBI | 3907 |
| CAS | 4434-05-3 |
| ChEMBL | CHEMBL389471 |
| Drug Class | aminocoumarin antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + aminocoumarin antibiotic [Drug Class] |
| Sub-Term(s) | 9 ontology terms | Show + antibiotic sensitive DNA topoisomerase subunit gyrB targeted_by_antibiotic + aminocoumarin sensitive parE targeted_by_antibiotic + aminocoumarin sensitive gyrB targeted_by_antibiotic + aminocoumarin sensitive parY targeted_by_antibiotic + Bartonella bacilliformis gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic + Escherichia coli gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic + Staphylococcus aureus gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic + Staphylococcus aureus parE conferring resistance to aminocoumarin confers_resistance_to_antibiotic + Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin confers_resistance_to_antibiotic |
| Publications | KAWAGUCHI H, et al. 1965. J Antibiot (Tokyo) 18: 1-10. STUDIES ON COUMERMYCIN, A NEW ANTIBIOTIC. I. PRODUCTION, ISOLATION AND CHARACTERIZATION OF COUMERMYCIN A1. (PMID 14285469) KAWAGUCHI H, et al. 1965. J Antibiot (Tokyo) 18: 11-25. STUDIES ON COUMERMYCIN. A NEW ANTIBIOTIC. II. STRUCTURE OF COUMERMYCIN A1. (PMID 14285468) Maxwell A. 1993. Mol Microbiol 9(4): 681-686. The interaction between coumarin drugs and DNA gyrase. (PMID 8231802) Wang ZX, et al. 2000. Antimicrob Agents Chemother 44(11): 3040-3048. Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489. (PMID 11036020) |
| Curator | Description | Most Recent Edit |
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