antibiotic sensitive DNA topoisomerase subunit parE

Accession ARO:3003259
DefinitionParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks.
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
3 ontology terms | Show

Schmutz E, et al. 2003. Antimicrob Agents Chemother 47(3): 869-877. Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. (PMID 12604514)