aminocoumarin resistant gyrB [AMR Gene Family]

Accession ARO:3000479
DefinitionPoint mutations in DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. These mutations usually involve arginine residues in organisms.
Drug Classaminocoumarin antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show
3 ontology terms | Show

Schmutz E, et al. 2003. Antimicrob Agents Chemother 47(3): 869-877. Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. (PMID 12604514)

Li SM and Heide L. 2006. Planta Med 72(12): 1093-1099. The biosynthetic gene clusters of aminocoumarin antibiotics. (PMID 16868863)

Sanfilippo CM, et al. 2011. Chemotherapy 57(5): 363-371. Topoisomerase Mutations That Are Associated with High-Level Resistance to Earlier Fluoroquinolones in Staphylococcus aureus Have Less Effect on the Antibacterial Activity of Besifloxacin. (PMID 21996946)

Schmutz E, et al. 2004. Microbiology 150(PT 3): 641-647. Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489. (PMID 14993313)

Alt S, et al. 2011. J Antimicrob Chemother 66(9): 2061-2069. Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics. (PMID 21693461)

Battisti JM, et al. 1998. Antimicrob Agents Chemother 42(11): 2906-2913. Mutations in Bartonella bacilliformis gyrB confer resistance to coumermycin A1. (PMID 9797224)