| Accession | ARO:3000479 |
| Definition | Point mutations in DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. These mutations usually involve arginine residues in organisms. |
| Drug Class | aminocoumarin antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic resistant gene variant or mutant + antibiotic resistant DNA topoisomerase subunit + antibiotic molecule |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_drug_class aminocoumarin antibiotic [Drug Class] + antibiotic resistant DNA topoisomerase subunit gyrB + derives_from aminocoumarin sensitive gyrB |
| Sub-Term(s) | 3 ontology terms | Show |
| Publications | Schmutz E, et al. 2003. Antimicrob Agents Chemother 47(3): 869-877. Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. (PMID 12604514) Li SM and Heide L. 2006. Planta Med 72(12): 1093-1099. The biosynthetic gene clusters of aminocoumarin antibiotics. (PMID 16868863) Sanfilippo CM, et al. 2011. Chemotherapy 57(5): 363-371. Topoisomerase Mutations That Are Associated with High-Level Resistance to Earlier Fluoroquinolones in Staphylococcus aureus Have Less Effect on the Antibacterial Activity of Besifloxacin. (PMID 21996946) Schmutz E, et al. 2004. Microbiology 150(PT 3): 641-647. Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489. (PMID 14993313) Alt S, et al. 2011. J Antimicrob Chemother 66(9): 2061-2069. Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics. (PMID 21693461) Battisti JM, et al. 1998. Antimicrob Agents Chemother 42(11): 2906-2913. Mutations in Bartonella bacilliformis gyrB confer resistance to coumermycin A1. (PMID 9797224) |
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