aminocoumarin resistant parY [AMR Gene Family]

Accession ARO:3000480
DefinitionExpression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can confer aminocoumarin resistance.
Drug Classaminocoumarin antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show
1 ontology terms | Show

Schmutz E, et al. 2004. Microbiology 150(PT 3): 641-647. Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489. (PMID 14993313)

Schmutz E, et al. 2003. Antimicrob Agents Chemother 47(3): 869-877. Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. (PMID 12604514)

Li SM and Heide L. 2006. Planta Med 72(12): 1093-1099. The biosynthetic gene clusters of aminocoumarin antibiotics. (PMID 16868863)