Accession ARO:3000524
DefinitionCpxAR is a two-component regulatory system that involves a sensor kinase, CpxA, and the regulator CpxR. When the membrane envelope is stressed, CpxAR promotes acrD and mdtABC expression to confer multidrug resistance through efflux.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classaminoglycoside antibiotic, aminocoumarin antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification16 ontology terms | Show
Parent Term(s)4 ontology terms | Show
2 ontology terms | Show
+ cpxA part_of
+ CpxR part_of

Hirakawa H, et al. 2003. J Bacteriol 185(6): 1851-1856. Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli. (PMID 12618449)

Srinivasan VB, et al. 2012. PLoS One 7(4): E33777. Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044. (PMID 22496764)