CpxR

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Accession ARO:3000831
DefinitionCpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA, a sensor kinase. CpxR is also directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, sulfonamide antibiotic, diaminopyrimidine antibiotic, aminocoumarin antibiotic, penicillin beta-lactam, cephalosporin, aminoglycoside antibiotic, phenicol antibiotic, tetracycline antibiotic, carbapenem, monobactam, fluoroquinolone antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification53 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ peptide antibiotic [Drug Class]
+ mechanism of antibiotic resistance
+ lipopeptide antibiotic
+ beta-lactam antibiotic
+ determinant of antibiotic resistance
+ antibiotic efflux [Resistance Mechanism]
+ antibiotic mixture
+ sulfonamide antibiotic [Drug Class]
+ diaminopyrimidine antibiotic [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ aminocoumarin antibiotic [Drug Class]
+ penicillin beta-lactam [Drug Class]
+ cephalosporin [Drug Class]
+ polymyxin antibiotic
+ aminoglycoside antibiotic [Drug Class]
+ penicillin with extended spectrum
+ third-generation cephalosporin
+ gentamicin [Antibiotic]
+ phenicol antibiotic [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ trimethoprim [Antibiotic]
+ novobiocin [Antibiotic]
+ tetracycline antibiotic [Drug Class]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ colistin
+ tobramycin [Antibiotic]
+ kanamycin A [Antibiotic]
+ carbapenem [Drug Class]
+ amikacin [Antibiotic]
+ neomycin [Antibiotic]
+ monobactam [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ macrolide antibiotic [Drug Class]
+ AcrAD-TolC
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ panipenem [Antibiotic]
+ MdtABC-TolC
+ ampicillin [Antibiotic]
+ colistin B [Antibiotic]
+ colistin A [Antibiotic]
+ aztreonam [Antibiotic]
+ acrD
+ protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ chloramphenicol [Antibiotic]
+ azithromycin [Antibiotic]
+ meropenem [Antibiotic]
+ ceftriaxone [Antibiotic]
+ ceftazidime [Antibiotic]
+ tetracycline [Antibiotic]
+ ciprofloxacin [Antibiotic]
+ erythromycin [Antibiotic]
Parent Term(s)3 ontology terms | Show
Sub-Term(s)
2 ontology terms | Show
Publications

Srinivasan VB, et al. 2012. PLoS One 7(4): E33777. Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044. (PMID 22496764)

Tian ZX, et al. 2016. PLoS Pathog. 12(10):e1005932 CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa. (PMID 27736975)

Weatherspoon-Griffin N, et al. 2014. J. Biol. Chem. 289(47):32571-82 The CpxR/CpxA two-component regulatory system up-regulates the multidrug resistance cascade to facilitate Escherichia coli resistance to a model antimicrobial peptide. (PMID 25294881)
Curator Acknowledgements
Curator Description Most Recent Edit