CpxR

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Accession ARO:3000831
DefinitionCpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA, a sensor kinase. CpxR is also directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, sulfonamide antibiotic, diaminopyrimidine antibiotic, aminocoumarin antibiotic, aminoglycoside antibiotic, phenicol antibiotic, tetracycline antibiotic, penam, cephalosporin, carbapenem, monobactam, fluoroquinolone antibiotic, macrolide antibiotic, penem, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification54 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ peptide antibiotic [Drug Class]
+ mechanism of antibiotic resistance
+ lipopeptide antibiotic
+ beta-lactam antibiotic
+ determinant of antibiotic resistance
+ antibiotic efflux [Resistance Mechanism]
+ antibiotic mixture
+ sulfonamide antibiotic [Drug Class]
+ cephem
+ diaminopyrimidine antibiotic [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ aminocoumarin antibiotic [Drug Class]
+ polymyxin antibiotic
+ aminoglycoside antibiotic [Drug Class]
+ gentamicin [Antibiotic]
+ phenicol antibiotic [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ trimethoprim [Antibiotic]
+ novobiocin [Antibiotic]
+ tetracycline antibiotic [Drug Class]
+ penam [Drug Class]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ colistin
+ tobramycin [Antibiotic]
+ kanamycin A [Antibiotic]
+ cephalosporin [Drug Class]
+ carbapenem [Drug Class]
+ amikacin [Antibiotic]
+ neomycin [Antibiotic]
+ monobactam [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ macrolide antibiotic [Drug Class]
+ AcrAD-TolC
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ panipenem [Antibiotic]
+ penem [Drug Class]
+ MdtABC-TolC
+ ampicillin [Antibiotic]
+ colistin B [Antibiotic]
+ colistin A [Antibiotic]
+ aztreonam [Antibiotic]
+ acrD
+ protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ chloramphenicol [Antibiotic]
+ azithromycin [Antibiotic]
+ meropenem [Antibiotic]
+ ceftriaxone [Antibiotic]
+ ceftazidime [Antibiotic]
+ tetracycline [Antibiotic]
+ cephamycin [Drug Class]
+ ciprofloxacin [Antibiotic]
+ erythromycin [Antibiotic]
Parent Term(s)3 ontology terms | Show
Sub-Term(s)
2 ontology terms | Show
Publications

Srinivasan VB, et al. 2012. PLoS One 7(4): E33777. Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044. (PMID 22496764)

Tian ZX, et al. 2016. PLoS Pathog. 12(10):e1005932 CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa. (PMID 27736975)

Weatherspoon-Griffin N, et al. 2014. J. Biol. Chem. 289(47):32571-82 The CpxR/CpxA two-component regulatory system up-regulates the multidrug resistance cascade to facilitate Escherichia coli resistance to a model antimicrobial peptide. (PMID 25294881)