Pseudomonas aeruginosa CpxR

Accession ARO:3004054
CARD Short NamePaer_CpxR
DefinitionCpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, aminoglycoside antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, tetracycline antibiotic, carbapenem, fluoroquinolone antibiotic, phenicol antibiotic, macrolide antibiotic, cephalosporin, monobactam, penam, cephamycin, penem
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Resistomes with Perfect MatchesPseudomonas aeruginosag+p+wgs, Pseudomonas fluorescensg
Resistomes with Sequence VariantsPseudomonas aeruginosag+p+wgs, Pseudomonas fluorescensg
Classification57 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ mechanism of antibiotic resistance
+ peptide antibiotic [Drug Class]
+ lipopeptide antibiotic
+ antibiotic efflux [Resistance Mechanism]
+ beta-lactam antibiotic
+ determinant of antibiotic resistance
+ aminoglycoside antibiotic [Drug Class]
+ cephem
+ aminocoumarin antibiotic [Drug Class]
+ antibiotic mixture
+ polymyxin antibiotic
+ diaminopyrimidine antibiotic [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ sulfonamide antibiotic [Drug Class]
+ kanamycin A [Antibiotic]
+ tetracycline antibiotic [Drug Class]
+ carbapenem [Drug Class]
+ colistin
+ fluoroquinolone antibiotic [Drug Class]
+ trimethoprim [Antibiotic]
+ phenicol antibiotic [Drug Class]
+ macrolide antibiotic [Drug Class]
+ tobramycin [Antibiotic]
+ gentamicin [Antibiotic]
+ cephalosporin [Drug Class]
+ monobactam [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ penam [Drug Class]
+ amikacin [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ neomycin [Antibiotic]
+ novobiocin [Antibiotic]
+ ciprofloxacin [Antibiotic]
+ colistin B [Antibiotic]
+ azithromycin [Antibiotic]
+ chloramphenicol [Antibiotic]
+ panipenem [Antibiotic]
+ cephamycin [Drug Class]
+ ampicillin [Antibiotic]
+ tetracycline [Antibiotic]
+ meropenem [Antibiotic]
+ ceftazidime [Antibiotic]
+ protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ AcrAD-TolC
+ aztreonam [Antibiotic]
+ MdtABC-TolC
+ erythromycin [Antibiotic]
+ colistin A [Antibiotic]
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ penem [Drug Class]
+ ceftriaxone [Antibiotic]
+ acrD
+ MexAB-OprM
+ protein of two-component regulatory system modulating antibiotic efflux
+ cpxAR
Parent Term(s)2 ontology terms | Show

Tian ZX, et al. 2016. PLoS Pathog. 12(10):e1005932 CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa. (PMID 27736975)


Prevalence of Pseudomonas aeruginosa CpxR among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Pseudomonas aeruginosa99.54%1.17%66.83%0%
Pseudomonas fluorescens2.78%0%0%0%
Show Perfect Only

Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400

>gb|SIP52035.1|-|Pseudomonas aeruginosa CpxR [Pseudomonas aeruginosa]

>gb|LT673656.1|-|1884345-1885022|Pseudomonas aeruginosa CpxR [Pseudomonas aeruginosa]