Escherichia coli CpxR

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Accession ARO:3004055
CARD Short NameEcol_CpxR
DefinitionThe Escherichia coli CpxR/CpxA system responds to general periplasmic stress and has been used as a model two-component system for transcription regulation in bacteria. CpxR/CpxA system facilitates Salmonella and E. coli resistance to cationic antimicrobial peptides.The CpxR/CpxA system can activate transcription of marRAB operon, thus facilitating multidrug-resistant regulator to enhance expression of TolC-dependent tripartite multidrug transporters.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, sulfonamide antibiotic, diaminopyrimidine antibiotic, aminocoumarin antibiotic, aminoglycoside antibiotic, phenicol antibiotic, tetracycline antibiotic, penam, cephalosporin, carbapenem, monobactam, fluoroquinolone antibiotic, macrolide antibiotic, penem, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification57 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ peptide antibiotic [Drug Class]
+ mechanism of antibiotic resistance
+ lipopeptide antibiotic
+ beta-lactam antibiotic
+ determinant of antibiotic resistance
+ antibiotic efflux [Resistance Mechanism]
+ antibiotic mixture
+ sulfonamide antibiotic [Drug Class]
+ cephem
+ diaminopyrimidine antibiotic [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ aminocoumarin antibiotic [Drug Class]
+ polymyxin antibiotic
+ aminoglycoside antibiotic [Drug Class]
+ gentamicin [Antibiotic]
+ phenicol antibiotic [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ trimethoprim [Antibiotic]
+ novobiocin [Antibiotic]
+ tetracycline antibiotic [Drug Class]
+ penam [Drug Class]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ colistin
+ tobramycin [Antibiotic]
+ kanamycin A [Antibiotic]
+ cephalosporin [Drug Class]
+ carbapenem [Drug Class]
+ amikacin [Antibiotic]
+ neomycin [Antibiotic]
+ monobactam [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ macrolide antibiotic [Drug Class]
+ AcrAD-TolC
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ panipenem [Antibiotic]
+ penem [Drug Class]
+ MdtABC-TolC
+ ampicillin [Antibiotic]
+ colistin B [Antibiotic]
+ colistin A [Antibiotic]
+ aztreonam [Antibiotic]
+ acrD
+ protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ chloramphenicol [Antibiotic]
+ azithromycin [Antibiotic]
+ meropenem [Antibiotic]
+ ceftriaxone [Antibiotic]
+ ceftazidime [Antibiotic]
+ tetracycline [Antibiotic]
+ cephamycin [Drug Class]
+ ciprofloxacin [Antibiotic]
+ erythromycin [Antibiotic]
+ protein of two-component regulatory system modulating antibiotic efflux
+ cpxAR
+ MexAB-OprM
Parent Term(s)1 ontology terms | Show
+ CpxR
Publications

Weatherspoon-Griffin N, et al. 2014. J. Biol. Chem. 289(47):32571-82 The CpxR/CpxA two-component regulatory system up-regulates the multidrug resistance cascade to facilitate Escherichia coli resistance to a model antimicrobial peptide. (PMID 25294881)

Private model - RGI is not currently using this model.