Escherichia coli CpxR

Accession ARO:3004055
CARD Short NameEcol_CpxR
DefinitionThe Escherichia coli CpxR/CpxA system responds to general periplasmic stress and has been used as a model two-component system for transcription regulation in bacteria. CpxR/CpxA system facilitates Salmonella and E. coli resistance to cationic antimicrobial peptides.The CpxR/CpxA system can activate transcription of marRAB operon, thus facilitating multidrug-resistant regulator to enhance expression of TolC-dependent tripartite multidrug transporters.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, aminoglycoside antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, carbapenem, phenicol antibiotic, monobactam, macrolide antibiotic, penam, fluoroquinolone antibiotic, tetracycline antibiotic, cephalosporin, cephamycin, penem
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification57 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ mechanism of antibiotic resistance
+ peptide antibiotic [Drug Class]
+ beta-lactam antibiotic
+ lipopeptide antibiotic
+ antibiotic efflux [Resistance Mechanism]
+ determinant of antibiotic resistance
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ aminoglycoside antibiotic [Drug Class]
+ polymyxin antibiotic
+ cephem
+ aminocoumarin antibiotic [Drug Class]
+ diaminopyrimidine antibiotic [Drug Class]
+ antibiotic mixture
+ sulfonamide antibiotic [Drug Class]
+ carbapenem [Drug Class]
+ neomycin [Antibiotic]
+ tobramycin [Antibiotic]
+ colistin
+ gentamicin [Antibiotic]
+ trimethoprim [Antibiotic]
+ amikacin [Antibiotic]
+ phenicol antibiotic [Drug Class]
+ kanamycin A [Antibiotic]
+ monobactam [Drug Class]
+ novobiocin [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ macrolide antibiotic [Drug Class]
+ penam [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ tetracycline antibiotic [Drug Class]
+ cephalosporin [Drug Class]
+ colistin B [Antibiotic]
+ protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ ceftazidime [Antibiotic]
+ colistin A [Antibiotic]
+ erythromycin [Antibiotic]
+ ceftriaxone [Antibiotic]
+ ciprofloxacin [Antibiotic]
+ AcrAD-TolC
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ ampicillin [Antibiotic]
+ cephamycin [Drug Class]
+ acrD
+ aztreonam [Antibiotic]
+ chloramphenicol [Antibiotic]
+ meropenem [Antibiotic]
+ azithromycin [Antibiotic]
+ tetracycline [Antibiotic]
+ MdtABC-TolC
+ panipenem [Antibiotic]
+ penem [Drug Class]
+ protein of two-component regulatory system modulating antibiotic efflux
+ cpxAR
+ MexAB-OprM
Parent Term(s)1 ontology terms | Show
+ CpxR

Weatherspoon-Griffin N, et al. 2014. J. Biol. Chem. 289(47):32571-82 The CpxR/CpxA two-component regulatory system up-regulates the multidrug resistance cascade to facilitate Escherichia coli resistance to a model antimicrobial peptide. (PMID 25294881)

Private model - RGI is not currently using this model.