| Accession | ARO:3002585 |
| CARD Short Name | AAC(6')-31 |
| Definition | AAC(6')-31 is an integron-encoded aminoglycoside acetyltransferase in Pseudomonas putida, A. baumannii and K. pneumoniae. |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniiwgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Acinetobacter radioresistenswgs, Aeromonas hydrophilawgs, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaep+wgs, Pseudomonas aeruginosawgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Acinetobacter radioresistenswgs, Aeromonas hydrophilawgs, Alcaligenes faecalisg, Citrobacter freundiip+wgs, Citrobacter portucalensiswgs, Enterobacter hormaecheiwgs, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaep+wgs, Pseudomonas aeruginosawgs+gi, Stenotrophomonas maltophiliawgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic inactivation enzyme + antibiotic molecule + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + aminoglycoside antibiotic [Drug Class] + antibiotic mixture + aminoglycoside acetyltransferase (AAC) |
| Parent Term(s) | 9 ontology terms | Show + AAC(6') [AMR Gene Family] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic neomycin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic sisomicin [Antibiotic] + confers_resistance_to_antibiotic isepamicin [Antibiotic] + confers_resistance_to_antibiotic gentamicin [Antibiotic] |
| Publications | Mendes RE, et al. 2007. Antimicrob Agents Chemother 51(7): 2611-2614. Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. (PMID 17470660) |
Prevalence of AAC(6')-31 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.01% | 0% |
| Acinetobacter nosocomialis | 0% | 0% | 1.15% | 0% |
| Acinetobacter pittii | 0% | 0% | 1.14% | 0% |
| Acinetobacter radioresistens | 0% | 0% | 1.75% | 0% |
| Aeromonas hydrophila | 0% | 0% | 0.81% | 0% |
| Alcaligenes faecalis | 5% | 0% | 0% | 0% |
| Citrobacter freundii | 0% | 0.31% | 0.19% | 0% |
| Citrobacter portucalensis | 0% | 0% | 0.9% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.04% | 0% |
| Escherichia coli | 0% | 0% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.03% | 0% |
| Klebsiella quasipneumoniae | 0% | 1.06% | 0.13% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.48% | 4.17% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.15% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 325