APH(3')-IIIa

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Accession ARO:3002647
CARD Short NameAPH(3')-IIIa
DefinitionAPH(3')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in S. aureus and Enterococcus spp.
AMR Gene FamilyAPH(3')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAnaerostipes hadruswgs, Bacillus cereuswgs, Bacillus subtilisg, Bacillus thuringiensiswgs, Bacillus velezensisg+wgs, Bacteroides fragiliswgs, Bacteroides thetaiotaomicronwgs, Bifidobacterium breveg+wgs, Bifidobacterium longumg+wgs, Butyricimonas faecalisg, Campylobacter colig+p+wgs, Campylobacter fetuswgs, Campylobacter jejunig+p+wgs, Corynebacterium pseudotuberculosisg, Eggerthella lentag+wgs, Enterocloster clostridioformisg+wgs, Enterococcus aviumwgs, Enterococcus faecalisg+p+wgs, Enterococcus faeciumg+p+wgs, Enterococcus hiraep+wgs, Erysipelothrix rhusiopathiaeg, Escherichia colip, Fusobacterium necrophorumwgs, Gordonibacter urolithinfacienswgs, Helicobacter pullorumwgs, Helicobacter pylorig+wgs, Klebsiella aerogeneswgs, Klebsiella pneumoniaewgs, Leptospira interroganswgs, Listeria innocuap, Neisseria brasiliensisg, Phocaeicola vulgatuswgs, Roseburia hominisg, Staphylococcus aureusg+p+wgs, Staphylococcus epidermidisg+p+wgs, Staphylococcus haemolyticusg+wgs, Staphylococcus hominisp+wgs, Staphylococcus lugdunensisg, Staphylococcus pseudintermediusg+wgs, Staphylococcus saprophyticuswgs, Staphylococcus warneriwgs, Streptococcus agalactiaeg+wgs, Streptococcus dysgalactiaeg+wgs, Streptococcus equiwgs, Streptococcus gallolyticuswgs, Streptococcus mitisg, Streptococcus mutanswgs, Streptococcus pasteurianuswgs, Streptococcus pneumoniaeg+wgs, Streptococcus pyogenesg+wgs, Streptococcus suisg+wgs
Resistomes with Sequence VariantsAnaerostipes hadruswgs, Bacillus cereuswgs, Bacillus subtilisg, Bacillus thuringiensiswgs, Bacillus velezensisg+wgs, Bacteroides fragiliswgs, Bacteroides thetaiotaomicronwgs, Bifidobacterium breveg+wgs, Bifidobacterium longumg+wgs, Butyricimonas faecalisg, Campylobacter colig+p+wgs, Campylobacter fetuswgs, Campylobacter jejunig+p+wgs, Corynebacterium pseudotuberculosisg, Eggerthella lentag+wgs, Enterocloster clostridioformisg+wgs, Enterococcus aviump+wgs, Enterococcus faecalisg+p+wgs, Enterococcus faeciumg+p+wgs, Enterococcus hiraep+wgs, Erysipelothrix rhusiopathiaeg, Escherichia colig+p+wgs, Fusobacterium necrophorumwgs, Gordonibacter urolithinfacienswgs, Helicobacter pullorumwgs, Helicobacter pylorig+wgs, Klebsiella aerogeneswgs, Klebsiella pneumoniaewgs, Leptospira interroganswgs, Listeria innocuap, Mycobacterium tuberculosiswgs, Neisseria brasiliensisg, Neisseria meningitidisg, Nocardia farcinicawgs, Phocaeicola doreiwgs, Phocaeicola vulgatuswgs, Roseburia hominisg, Salmonella entericawgs, Staphylococcus aureusg+p+wgs, Staphylococcus epidermidisg+p+wgs, Staphylococcus haemolyticusg+wgs, Staphylococcus hominisp+wgs, Staphylococcus lugdunensisg, Staphylococcus pseudintermediusg+wgs, Staphylococcus saprophyticuswgs, Staphylococcus warneriwgs, Stenotrophomonas maltophiliawgs, Streptococcus agalactiaeg+wgs, Streptococcus dysgalactiaeg+wgs, Streptococcus equiwgs, Streptococcus gallolyticuswgs, Streptococcus mitisg, Streptococcus mutanswgs, Streptococcus pasteurianuswgs, Streptococcus pneumoniaeg+wgs, Streptococcus pyogenesg+wgs, Streptococcus suisg+wgs
Classification13 ontology terms | Show
Parent Term(s)10 ontology terms | Show
+ confers_resistance_to_antibiotic kanamycin A [Antibiotic]
+ confers_resistance_to_antibiotic neomycin [Antibiotic]
+ confers_resistance_to_antibiotic paromomycin [Antibiotic]
+ confers_resistance_to_antibiotic ribostamycin [Antibiotic]
+ confers_resistance_to_antibiotic lividomycin [Antibiotic]
+ confers_resistance_to_antibiotic butirosin [Antibiotic]
+ confers_resistance_to_antibiotic gentamicin B [Antibiotic]
+ confers_resistance_to_antibiotic amikacin [Antibiotic]
+ confers_resistance_to_antibiotic isepamicin [Antibiotic]
+ APH(3')-III
Sub-Term(s)
1 ontology terms | Show
+ quercetin [Adjuvant] is_small_molecule_inhibitor
Publications

Trieu-Cuot P and Courvalin P. 1983. Gene 23(3): 331-341. Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5-aminoglycoside phosphotransferase type III. (PMID 6313476)

Resistomes

Prevalence of APH(3')-IIIa among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Anaerostipes hadrus0%0%1.82%0%
Bacillus cereus0%0%0.09%0%
Bacillus subtilis0.9%0%0%0%
Bacillus thuringiensis0%0%0.16%0%
Bacillus velezensis0.82%0%0.46%0%
Bacteroides fragilis0%0%0.36%0%
Bacteroides thetaiotaomicron0%0%4.3%0%
Bifidobacterium breve6.25%0%1.79%0%
Bifidobacterium longum8.79%0%0.88%0%
Butyricimonas faecalis100%0%0%0%
Campylobacter coli18.03%9%10.18%0%
Campylobacter fetus0%0%1.32%0%
Campylobacter jejuni4.8%18.95%4.07%0%
Corynebacterium pseudotuberculosis0.87%0%0%0%
Eggerthella lenta10%0%5.71%0%
Enterocloster clostridioformis100%0%14.29%0%
Enterococcus avium0%33.33%5.41%0%
Enterococcus faecalis11.59%14.9%13.4%0%
Enterococcus faecium2.52%12.23%31.04%0%
Enterococcus hirae0%6.45%1.52%0%
Erysipelothrix rhusiopathiae27.27%0%0%0%
Escherichia coli0.5%0.01%0.04%0%
Fusobacterium necrophorum0%0%7.32%0%
Gordonibacter urolithinfaciens0%0%45.45%0%
Helicobacter pullorum0%0%13.64%0%
Helicobacter pylori1.3%0%0.49%0%
Klebsiella aerogenes0%0%0.31%0%
Klebsiella pneumoniae0%0%0.03%0%
Leptospira interrogans0%0%0.66%0%
Listeria innocua0%12.5%0%0%
Mycobacterium tuberculosis0%0%0.02%0%
Neisseria brasiliensis100%0%0%0%
Neisseria meningitidis0.76%0%0%0%
Nocardia farcinica0%0%2.63%0%
Phocaeicola dorei0%0%1.14%0%
Phocaeicola vulgatus0%0%1.93%0%
Roseburia hominis100%0%0%0%
Salmonella enterica0%0%0.02%0%
Staphylococcus aureus8.06%3.11%12.91%0%
Staphylococcus epidermidis0.91%0.78%3.5%0%
Staphylococcus haemolyticus25%0%20.22%0%
Staphylococcus hominis0%2.17%4.62%0%
Staphylococcus lugdunensis3.33%0%0%0%
Staphylococcus pseudintermedius43.4%0%56.35%0%
Staphylococcus saprophyticus0%0%0.75%0%
Staphylococcus warneri0%0%2.63%0%
Stenotrophomonas maltophilia0%0%0.17%0%
Streptococcus agalactiae5.21%0%7.37%0%
Streptococcus dysgalactiae2.56%0%2.06%0%
Streptococcus equi0%0%0.23%0%
Streptococcus gallolyticus0%0%20%0%
Streptococcus mitis11.11%0%0%0%
Streptococcus mutans0%0%0.85%0%
Streptococcus pasteurianus0%0%21.43%0%
Streptococcus pneumoniae2.56%0%0.78%0%
Streptococcus pyogenes1.96%0%0.67%0%
Streptococcus suis12.5%0%6.73%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|AGV10830.1|+|APH(3')-IIIa [Campylobacter coli CVM N29710]
MAKMRISPELKKLIEKYRCVKDTEGMSPAKVYKLVGENENLYLKMTDSRYKGTTYDVEREKDMMLWLEGKLPVPKVLHFERHDGWSNLLM
SEADGVLCSEEYEDEQSPEKIIELYAECIRLFHSIDISDCPYTNSLDSRLAELDYLLNNDLADVDCENWEEDTPFKDPRELYDFLKTEKP
EEELVFSHGDLGDSNIFVKDGKVSGFIDLGRSGRADKWYDIAFCVRSIREDIGEEQYVELFFDLLGIKPDWEKIKYYILLDELF


>gb|CP004067.1|+|52915-53709|APH(3')-IIIa [Campylobacter coli CVM N29710]
ATGGCTAAAATGAGAATATCACCGGAATTGAAAAAACTGATCGAAAAATACCGCTGCGTAAAAGATACGGAAGGAATGTCTCCTGCTAAG
GTATATAAGCTGGTGGGAGAAAATGAAAACCTATATTTAAAAATGACGGACAGCCGGTATAAAGGGACCACCTATGATGTGGAACGGGAA
AAGGACATGATGCTATGGCTGGAAGGAAAGCTGCCTGTTCCAAAGGTCCTGCACTTTGAACGGCATGATGGCTGGAGCAATCTGCTCATG
AGTGAGGCCGATGGCGTCCTTTGCTCGGAAGAGTATGAAGATGAACAAAGCCCTGAAAAGATTATCGAGCTGTATGCGGAGTGCATCAGG
CTCTTTCACTCCATCGACATATCGGATTGTCCCTATACGAATAGCTTAGACAGCCGCTTAGCCGAATTGGATTACTTACTGAATAACGAT
CTGGCCGATGTGGATTGCGAAAACTGGGAAGAAGACACTCCATTTAAAGATCCGCGCGAGCTGTATGATTTTTTAAAGACGGAAAAGCCC
GAAGAGGAACTTGTCTTTTCCCACGGCGACCTGGGAGACAGCAACATCTTTGTGAAAGATGGCAAAGTAAGTGGCTTTATTGATCTTGGG
AGAAGCGGCAGGGCGGACAAGTGGTATGACATTGCCTTCTGCGTCCGGTCGATCAGGGAGGATATCGGGGAAGAACAGTATGTCGAGCTA
TTTTTTGACTTACTGGGGATCAAGCCTGATTGGGAGAAAATAAAATATTATATTTTACTGGATGAATTGTTTTAG