| Accession | ARO:3000657 |
| Synonym(s) | hydroxymycin paucimycin estomycin aminosidin Gabbomycin Humatin aminosidine crestomycin neomycin E monomycin A catenulin Humagel |
| Definition | An aminoglycoside antibiotic used for the treatment of parasitic infections. It is similar to neomycin sharing a similar spectrum of activity, but its hydroxyl group at the 6'-position instead of an amino group makes it resistant to AAC(6') modifying enzymes. |
| Drug Class | aminoglycoside antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + aminoglycoside antibiotic [Drug Class] |
| Sub-Term(s) | 17 ontology terms | Show + antibiotic sensitive 16S rRNA targeted_by_antibiotic + Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin confers_resistance_to_antibiotic + APH(3')-Vb confers_resistance_to_antibiotic + APH(3')-Va confers_resistance_to_antibiotic + APH(3')-Vc confers_resistance_to_antibiotic + APH(3')-VIa confers_resistance_to_antibiotic + APH(3')-VIb confers_resistance_to_antibiotic + AAC(3)-VIIa confers_resistance_to_antibiotic + AAC(3)-IIIa confers_resistance_to_antibiotic + AAC(3)-IIIb confers_resistance_to_antibiotic + APH(3')-Ia confers_resistance_to_antibiotic + APH(3')-Ib confers_resistance_to_antibiotic + APH(3')-IIa confers_resistance_to_antibiotic + APH(3')-IIb confers_resistance_to_antibiotic + APH(3')-IIc confers_resistance_to_antibiotic + APH(3')-IIIa confers_resistance_to_antibiotic + APH(3')-IVa confers_resistance_to_antibiotic |
| Publications | Kayok TP, et al. 1994. J Antimicrob Chemother 33(2): 323-327. Activity of aminosidine (paromomycin) for Mycobacterium tuberculosis and Mycobacterium avium. (PMID 8182014) Donald PR, et al. 2000. Antimicrob Agents Chemother 44(12): 3285-3287. Early bactericidal activity of paromomycin (aminosidine) in patients with smear-positive pulmonary tuberculosis. (PMID 11083628) |
