paromomycin [Antibiotic]

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Accession ARO:3000657
Synonym(s)hydroxymycin paucimycin estomycin aminosidin Gabbomycin Humatin aminosidine crestomycin neomycin E monomycin A catenulin Humagel
DefinitionAn aminoglycoside antibiotic used for the treatment of parasitic infections. It is similar to neomycin sharing a similar spectrum of activity, but its hydroxyl group at the 6'-position instead of an amino group makes it resistant to AAC(6') modifying enzymes.
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
17 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin confers_resistance_to_antibiotic
+ APH(3')-Vb confers_resistance_to_antibiotic
+ APH(3')-Va confers_resistance_to_antibiotic
+ APH(3')-Vc confers_resistance_to_antibiotic
+ APH(3')-VIa confers_resistance_to_antibiotic
+ APH(3')-VIb confers_resistance_to_antibiotic
+ AAC(3)-VIIa confers_resistance_to_antibiotic
+ AAC(3)-IIIa confers_resistance_to_antibiotic
+ AAC(3)-IIIb confers_resistance_to_antibiotic
+ APH(3')-Ia confers_resistance_to_antibiotic
+ APH(3')-Ib confers_resistance_to_antibiotic
+ APH(3')-IIa confers_resistance_to_antibiotic
+ APH(3')-IIb confers_resistance_to_antibiotic
+ APH(3')-IIc confers_resistance_to_antibiotic
+ APH(3')-IIIa confers_resistance_to_antibiotic
+ APH(3')-IVa confers_resistance_to_antibiotic

Kayok TP, et al. 1994. J Antimicrob Chemother 33(2): 323-327. Activity of aminosidine (paromomycin) for Mycobacterium tuberculosis and Mycobacterium avium. (PMID 8182014)

Donald PR, et al. 2000. Antimicrob Agents Chemother 44(12): 3285-3287. Early bactericidal activity of paromomycin (aminosidine) in patients with smear-positive pulmonary tuberculosis. (PMID 11083628)