| Accession | ARO:3005116 |
| CARD Short Name | AAC(6')-Ib-cr6 |
| Definition | A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Escherichia coli. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. |
| AMR Gene Family | AAC(6'), AAC(6')-Ib-cr |
| Drug Class | aminoglycoside antibiotic, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Acinetobacter nosocomialiswgs, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilag+p+wgs, Aeromonas veroniig+p+wgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniip+wgs, Citrobacter youngaewgs, Enterobacter asburiaeg+p+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella huaxiensisg, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+p+wgs, Laribacter hongkongensisg+wgs, Leclercia adecarboxylatap+wgs, Morganella morganiig+p+wgs, Proteus mirabilisg+p+wgs, Proteus penneriwgs, Providencia alcalifaciensg, Providencia rettgerig+p+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosawgs, Pseudomonas putidap, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia marcescensp+wgs, Shigella boydiiwgs, Shigella flexnerip+wgs, Shigella sonneiwgs, Vibrio choleraep+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside antibiotic [Drug Class] + aminoglycoside acetyltransferase (AAC) + fluoroquinolone antibiotic [Drug Class] + AAC(6') [AMR Gene Family] |
| Parent Term(s) | 5 ontology terms | Show + AAC(6')-Ib-cr [AMR Gene Family] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] |
| Publications | Tegha G, et al. 2021. Microb Genom 7(1): Genomic epidemiology of Escherichia coli isolates from a tertiary referral center in Lilongwe, Malawi. (PMID 33295867) |
Prevalence of AAC(6')-Ib-cr6 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.07% | 0% |
| Acinetobacter nosocomialis | 0% | 0% | 0.57% | 0% |
| Aeromonas caviae | 2.27% | 2.6% | 3.76% | 0% |
| Aeromonas hydrophila | 3.08% | 1.3% | 1.61% | 0% |
| Aeromonas veronii | 5.45% | 1.54% | 1.69% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 5.45% | 0% |
| Citrobacter freundii | 0% | 8.92% | 13.73% | 0% |
| Citrobacter koseri | 0% | 15% | 7.21% | 0% |
| Citrobacter portucalensis | 0% | 16.18% | 13.51% | 0% |
| Citrobacter werkmanii | 0% | 10% | 12.82% | 0% |
| Citrobacter youngae | 0% | 0% | 6.25% | 0% |
| Enterobacter asburiae | 3.23% | 1.1% | 2.37% | 0% |
| Enterobacter chengduensis | 0% | 0% | 8% | 0% |
| Enterobacter cloacae | 1.79% | 1.68% | 5.75% | 0% |
| Enterobacter hormaechei | 1.8% | 2.57% | 7.85% | 0% |
| Enterobacter kobei | 0% | 1.38% | 3.06% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 1.8% | 0% |
| Escherichia coli | 0.93% | 1.43% | 3.24% | 0% |
| Escherichia fergusonii | 0% | 0.36% | 2.17% | 0% |
| Klebsiella aerogenes | 2% | 5.43% | 1.98% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 0% | 0% |
| Klebsiella michiganensis | 0% | 10.86% | 7.18% | 0% |
| Klebsiella oxytoca | 2.56% | 6.16% | 1.68% | 0% |
| Klebsiella pneumoniae | 4.79% | 5.41% | 11.24% | 0% |
| Klebsiella quasipneumoniae | 0.84% | 2.97% | 8.55% | 0% |
| Laribacter hongkongensis | 66.67% | 0% | 4.17% | 0% |
| Leclercia adecarboxylata | 0% | 9.52% | 4.65% | 0% |
| Morganella morganii | 25% | 5% | 7.36% | 0% |
| Proteus mirabilis | 33.94% | 8.75% | 6.44% | 0% |
| Proteus penneri | 0% | 0% | 25% | 0% |
| Providencia alcalifaciens | 18.18% | 0% | 0% | 0% |
| Providencia rettgeri | 5.88% | 5.41% | 1.27% | 0% |
| Providencia stuartii | 0% | 0% | 6.82% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.16% | 0% |
| Pseudomonas putida | 0% | 4% | 0% | 0% |
| Raoultella planticola | 0% | 11.63% | 10.26% | 0% |
| Salmonella enterica | 1.14% | 3.56% | 0.82% | 0% |
| Serratia marcescens | 0% | 1.29% | 0.92% | 0% |
| Shigella boydii | 0% | 0% | 1.11% | 0% |
| Shigella flexneri | 0% | 3.21% | 0.47% | 0% |
| Shigella sonnei | 0% | 0% | 0.22% | 0% |
| Vibrio cholerae | 0% | 5.26% | 0.13% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300