| Accession | ARO:3002581 |
| CARD Short Name | AAC(6')-Ib10 |
| Definition | AAC(6')-Ib10 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs+gi, Acinetobacter pittiiwgs, Aeromonas caviaeg+wgs, Aeromonas hydrophilag+wgs, Aeromonas veroniig+p+wgs, Citrobacter amalonaticuswgs, Citrobacter freundiip+wgs, Citrobacter koseriwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Cronobacter malonaticuswgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Klebsiella aerogenesp+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatawgs, Morganella morganiig+p+wgs, Proteus mirabilisg+p+wgs, Providencia heimbachaep, Providencia rettgerig+wgs, Providencia stuartiip+wgs, Pseudomonas aeruginosag+p+wgs+gi, Pseudomonas monteiliiwgs, Pseudomonas stutzeriwgs, Raoultella planticolawgs, Salmonella entericag+p+wgs, Serratia marcescensp+wgs, Shigella flexnerip+wgs, Vibrio choleraewgs, Vibrio vulnificuswgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + AAC(6') [AMR Gene Family] |
| Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + AAC(6')-I |
| Publications | Mugnier P, et al. 1998. Microbiology 144(PT 4): 1021-1031. Carbapenems as inhibitors of OXA-13, a novel, integron-encoded beta-lactamase in Pseudomonas aeruginosa. (PMID 9579076) |
Prevalence of AAC(6')-Ib10 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 1.06% | 0.42% | 0.87% | 1.26% |
| Acinetobacter pittii | 0% | 0% | 0.85% | 0% |
| Aeromonas caviae | 4.55% | 0% | 3.23% | 0% |
| Aeromonas hydrophila | 4.62% | 0% | 0.81% | 0% |
| Aeromonas veronii | 1.82% | 1.54% | 0.56% | 0% |
| Citrobacter amalonaticus | 0% | 0% | 1.82% | 0% |
| Citrobacter freundii | 0% | 0.31% | 2.32% | 0% |
| Citrobacter koseri | 0% | 0% | 0.9% | 0% |
| Citrobacter portucalensis | 0% | 0% | 3.6% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Cronobacter malonaticus | 0% | 0% | 1.82% | 0% |
| Enterobacter asburiae | 0% | 0.55% | 5.53% | 0% |
| Enterobacter chengduensis | 0% | 0% | 8% | 0% |
| Enterobacter cloacae | 1.79% | 2.23% | 4.79% | 0% |
| Enterobacter hormaechei | 0.36% | 1.87% | 7.16% | 0% |
| Enterobacter kobei | 0% | 0.69% | 6.99% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 3.96% | 0% |
| Escherichia coli | 0.05% | 0.26% | 0.57% | 0% |
| Escherichia fergusonii | 0% | 0% | 2.17% | 0% |
| Klebsiella aerogenes | 0% | 4.35% | 2.54% | 0% |
| Klebsiella michiganensis | 0% | 2.29% | 1.33% | 0% |
| Klebsiella oxytoca | 0% | 1.37% | 0.84% | 0% |
| Klebsiella pneumoniae | 1.12% | 3.61% | 12.42% | 0.95% |
| Klebsiella quasipneumoniae | 0% | 1.27% | 4.47% | 0% |
| Leclercia adecarboxylata | 0% | 0% | 4.65% | 0% |
| Morganella morganii | 1.92% | 10% | 3.07% | 0% |
| Proteus mirabilis | 1.83% | 6.25% | 1.98% | 0% |
| Providencia heimbachae | 0% | 100% | 0% | 0% |
| Providencia rettgeri | 2.94% | 0% | 2.55% | 0% |
| Providencia stuartii | 0% | 9.09% | 11.36% | 0% |
| Pseudomonas aeruginosa | 1.23% | 1.17% | 1.11% | 8.33% |
| Pseudomonas monteilii | 0% | 0% | 4.76% | 0% |
| Pseudomonas stutzeri | 0% | 0% | 1.53% | 0% |
| Raoultella planticola | 0% | 0% | 2.56% | 0% |
| Salmonella enterica | 0.06% | 0.22% | 0.06% | 0% |
| Serratia marcescens | 0% | 1.94% | 2.1% | 0% |
| Shigella flexneri | 0% | 0.8% | 0.47% | 0% |
| Vibrio cholerae | 0% | 0% | 0.19% | 0% |
| Vibrio vulnificus | 0% | 0% | 0.41% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 275