Escherichia coli mipA

Accession ARO:3004127
CARD Short NameEcol_mipA
DefinitionMltA-interacting protein (mipA), is an antibiotic resistance-related outer membrane protein. Deletion of mipA increases kanamycin, nalidixic acid and streptomycin resistance.
AMR Gene FamilyMipA-interacting Protein
Drug Classaminoglycoside antibiotic, fluoroquinolone antibiotic
Resistance Mechanismreduced permeability to antibiotic, resistance by absence
Classification9 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ gene conferring resistance via absence
+ confers_resistance_to_antibiotic kanamycin A [Antibiotic]
+ confers_resistance_to_antibiotic nalidixic acid [Antibiotic]
+ confers_resistance_to_antibiotic streptomycin [Antibiotic]
+ MipA-interacting Protein [AMR Gene Family]

Li H, et al. 2015. FEMS Microbiol. Lett. 362(11): Outer membrane proteomics of kanamycin-resistant Escherichia coli identified MipA as a novel antibiotic resistance-related protein. (PMID 25940639)


Prevalence of Escherichia coli mipA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein knockout model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data

Detection Models

Model Type: protein knockout model

Model Definition: Protein Knockout Models (PKM) reflect resistance by the absence of a gene product, most often deletion of a gene involved in antibiotic import, such as Vibrio cholerae OmpT. Like Protein Homolog Models (PHMs), PKMs include a reference sequence and a bitscore cut-off for detection using BLASTP but instead are designed to only report lack of detection under Perfect or Strict criteria. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software.

Bit-score Cut-off (blastP): 450

Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded

>gb|NP_310518.1|-|Escherichia coli mipA [Escherichia coli O157:H7 str. Sakai]

>gb|NC_002695.2|-|2467468-2468214|Escherichia coli mipA [Escherichia coli O157:H7 str. Sakai]