| Accession | ARO:3002547 |
| CARD Short Name | AAC(6')-Ib-cr1 |
| Definition | AAC(6')-Ib-cr is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Enterobacteriaceae. The aac(6')-Ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously. |
| AMR Gene Family | AAC(6'), AAC(6')-Ib-cr |
| Drug Class | aminoglycoside antibiotic, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Aeromonas veroniigi, Enterobacter hormaecheigi, Escherichia coligi, Klebsiella huaxiensisgi, Klebsiella pneumoniaegi, Laribacter hongkongensisgi, Morganella morganiigi, Proteus mirabilisgi, Salmonella entericagi |
| Resistomes with Sequence Variants | Aeromonas veroniigi, Enterobacter hormaecheigi, Escherichia coliwgs+gi, Klebsiella huaxiensisgi, Klebsiella pneumoniaewgs+gi, Laribacter hongkongensisgi, Morganella morganiigi, Proteus mirabilisgi, Salmonella entericagi |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + acylation of antibiotic conferring resistance + aminoglycoside modifying enzyme + antibiotic molecule + aminoglycoside antibiotic [Drug Class] + aminoglycoside acetyltransferase (AAC) + fluoroquinolone antibiotic [Drug Class] + AAC(6') [AMR Gene Family] |
| Parent Term(s) | 5 ontology terms | Show + AAC(6')-Ib-cr [AMR Gene Family] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] |
| Publications | Robicsek A, et al. 2006. Nat Med 12(1): 83-88. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. (PMID 16369542) Shen P, et al. 2008. J Antimicrob Chemother 62(6): 1252-1256. Complete nucleotide sequence of pKP96, a 67 850 bp multiresistance plasmid encoding qnrA1, aac(6')-Ib-cr and blaCTX-M-24 from Klebsiella pneumoniae. (PMID 18812424) Vetting MW, et al. 2008. Biochemistry 47(37): 9825-9835. Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant. (PMID 18710261) |
Prevalence of AAC(6')-Ib-cr1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aeromonas veronii | 0% | 0% | 0% | 12.5% |
| Enterobacter hormaechei | 0% | 0% | 0% | 6.67% |
| Escherichia coli | 0% | 0% | 0.01% | 1.15% |
| Klebsiella huaxiensis | 0% | 0% | 0% | 50% |
| Klebsiella pneumoniae | 0% | 0% | 0.05% | 5.71% |
| Laribacter hongkongensis | 0% | 0% | 0% | 50% |
| Morganella morganii | 0% | 0% | 0% | 7.69% |
| Proteus mirabilis | 0% | 0% | 0% | 25.93% |
| Salmonella enterica | 0% | 0% | 0% | 2.65% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 275
