Accession ARO:3002576
Synonym(s)AAC(6')-Ib5 aacA4
DefinitionAAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa
AMR Gene FamilyAAC(6')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniig+wgs, Citrobacter freundiip, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosawgs, Serratia marcescenswgs, Shigella sonneiwgs
Resistomes with Sequence VariantsAcinetobacter baumanniig+wgs, Citrobacter freundiip+wgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Escherichia coliwgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosawgs, Pseudomonas putidawgs, Serratia marcescenswgs, Shigella sonneiwgs
Classification19 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ AAC(6') [AMR Gene Family]

Casin I, et al. 1998. Antimicrob Agents Chemother 42(2): 209-215. Aminoglycoside 6'-N-acetyltransferase variants of the Ib type with altered substrate profile in clinical isolates of Enterobacter cloacae and Citrobacter freundii. (PMID 9527761)

Mabilat C, et al. 1992. Mol Gen Genet 235(1): 113-121. A new example of physical linkage between Tn1 and Tn21: the antibiotic multiple-resistance region of plasmid pCFF04 encoding extended-spectrum beta-lactamase TEM-3. (PMID 1331747)


Prevalence of AAC(6')-Ib3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 88 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Acinetobacter baumannii0.54%0%0.12%
Citrobacter freundii0%0.94%0.64%
Enterobacter cloacae0%0%0.2%
Enterobacter hormaechei0%0%0.61%
Escherichia coli0%0%0.03%
Klebsiella pneumoniae0%0%0.21%
Pseudomonas aeruginosa0%0%0.33%
Pseudomonas putida0%0%2.08%
Serratia marcescens0%0%1.28%
Shigella sonnei0%0%0.08%
Show Perfect Only

Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 275

>gb|ACS44715.1|+|AAC(6')-Ib3 [Acinetobacter baumannii]

>gb|FJ854362|+|1703-2257|AAC(6')-Ib3 [Acinetobacter baumannii]