Accession ARO:3003676
DefinitionAAC(6')-Ib' is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in P. aeruginosa and P. fluorescens.
AMR Gene FamilyAAC(6')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniiwgs, Enterobacter cloacaewgs, Escherichia colip, Klebsiella pneumoniaep+wgs, Mycobacteroides abscessusp, Pseudomonas aeruginosawgs, Salmonella entericawgs
Resistomes with Sequence VariantsAcinetobacter baumanniip+wgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Escherichia colip, Klebsiella pneumoniaep+wgs, Mycobacteroides abscessusp, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Salmonella entericawgs
Classification19 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic amikacin [Antibiotic]
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
+ AAC(6') [AMR Gene Family]

MacLeod DL, et al. 2000. J. Infect. Dis. 181(3):1180-4 Aminoglycoside-resistance mechanisms for cystic fibrosis Pseudomonas aeruginosa isolates are unchanged by long-term, intermittent, inhaled tobramycin treatment. (PMID 10720551)

Lambert T, et al. 1994. FEMS Microbiol Lett 115(2-3): 297-304. A spontaneous point mutation in the aac(6')-Ib' gene results in altered substrate specificity of aminoglycoside 6'-N-acetyltransferase of a Pseudomonas fluorescens strain. (PMID 8138142)


Prevalence of AAC(6')-Ib' among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 88 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Acinetobacter baumannii0%0.24%0.39%
Enterobacter cloacae0%0%0.78%
Enterobacter hormaechei0%0%0.37%
Escherichia coli0%0.01%0%
Klebsiella pneumoniae0%0.39%0.32%
Mycobacteroides abscessus0%15.38%0%
Providencia rettgeri0%0%3.12%
Pseudomonas aeruginosa0%0%0.77%
Salmonella enterica0%0%0.05%
Show Perfect Only

Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 275

>gb|AAT74613.1|+|AAC(6')-Ib' [Pseudomonas aeruginosa]

>gb|AY660529.1|+|122-676|AAC(6')-Ib' [Pseudomonas aeruginosa]