AAC(6')-Iae

Accession ARO:3002573
CARD Short NameAAC(6')-Iae
DefinitionAAC(6')-Iae is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa and S. enterica.
AMR Gene FamilyAAC(6')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesEnterobacter hormaecheip, Providencia stuartiip
Resistomes with Sequence VariantsEnterobacter hormaecheip, Providencia stuartiip
Classification9 ontology terms | Show
Parent Term(s)8 ontology terms | Show
+ confers_resistance_to_antibiotic dibekacin [Antibiotic]
+ confers_resistance_to_antibiotic amikacin [Antibiotic]
+ confers_resistance_to_antibiotic sisomicin [Antibiotic]
+ confers_resistance_to_antibiotic netilmicin [Antibiotic]
+ confers_resistance_to_antibiotic kanamycin A [Antibiotic]
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
+ AAC(6') [AMR Gene Family]
+ confers_resistance_to_antibiotic isepamicin [Antibiotic]
Publications

Sekiguchi J, et al. 2005. Antimicrob Agents Chemother 49(9): 3734-3742. Multidrug-resistant Pseudomonas aeruginosa strain that caused an outbreak in a neurosurgery ward and its aac(6')-Iae gene cassette encoding a novel aminoglycoside acetyltransferase. (PMID 16127047)

Resistomes

Prevalence of AAC(6')-Iae among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Enterobacter hormaechei0%0.13%0%0%
Providencia stuartii0%3.57%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 275


>gb|BAD14386.1|+|AAC(6')-Iae [Pseudomonas aeruginosa]
MKYNIVNIKDSEKYITQAAEILFDVFSHINFDSWPSLQKATETVIECISAENICIGILINDELCGWVGLREMYKKTWELHPMVIKKKHQN
KGFGKILIFETEKKAKERNLEGIVLGTDDETFRTTLSMSELNNENIFHEIKNIKNLKNHPFEFYEKCGYSIIGVIPNANGKNKPDILMWK
NIM


>gb|AB104852.1|+|1935-2486|AAC(6')-Iae [Pseudomonas aeruginosa]
ATGAAATACAACATTGTTAATATTAAAGATTCTGAAAAGTATATAACGCAAGCTGCAGAAATTCTATTTGATGTATTTTCACACATAAAT
TTCGATTCTTGGCCGTCACTCCAAAAGGCTACAGAAACTGTAATAGAATGTATTAGCGCCGAAAACATTTGTATTGGCATTTTAATAAAC
GATGAATTGTGTGGTTGGGTTGGATTAAGAGAAATGTATAAAAAAACTTGGGAACTACATCCAATGGTTATTAAGAAAAAACATCAAAAT
AAGGGATTTGGTAAAATACTAATTTTTGAAACAGAAAAGAAAGCGAAAGAAAGAAATTTAGAAGGAATTGTACTTGGAACAGACGATGAA
ACATTTAGAACTACATTATCAATGTCAGAATTAAATAATGAAAATATATTCCATGAAATTAAAAATATAAAAAATCTAAAAAATCATCCA
TTTGAATTTTATGAAAAATGTGGTTACAGTATTATTGGTGTGATTCCTAATGCAAATGGGAAAAATAAACCTGATATATTAATGTGGAAA
AATATAATGTAA