| Accession | ARO:3002545 |
| Synonym(s) | aacA1 |
| CARD Short Name | AAC(6')-Ia |
| Definition | AAC(6')-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Citrobacter diversus, E. coli, K. pneumoniae, Shigella sonnei, and P. aeruginosa. |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Aeromonas caviaep, Aeromonas veroniip, Enterobacter cloacaep+wgs, Enterobacter kobeiwgs, Klebsiella pneumoniaep+wgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs |
| Resistomes with Sequence Variants | Aeromonas caviaep, Aeromonas veroniip, Enterobacter cloacaep+wgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Escherichia coliwgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Vibrio parahaemolyticuswgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + AAC(6') [AMR Gene Family] |
| Parent Term(s) | 8 ontology terms | Show + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic sisomicin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic 2'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic 5-episisomicin [Antibiotic] + AAC(6')-I |
| Publications | Tenover FC, et al. 1988. J Bacteriol 170(1): 471-473. Cloning and sequencing of a gene encoding an aminoglycoside 6'-N-acetyltransferase from an R factor of Citrobacter diversus. (PMID 2826403) Parent R and Roy PH. 1992. J Bacteriol 174(9): 2891-2897. The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat. (PMID 1314803) |
Prevalence of AAC(6')-Ia among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aeromonas caviae | 0% | 2.6% | 0% | 0% |
| Aeromonas veronii | 0% | 1.54% | 0% | 0% |
| Enterobacter cloacae | 0% | 1.68% | 0.32% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.09% | 0% |
| Enterobacter kobei | 0% | 0% | 0.44% | 0% |
| Escherichia coli | 0% | 0% | 0.01% | 0% |
| Klebsiella pneumoniae | 0% | 0.01% | 0.01% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.26% | 0% |
| Providencia rettgeri | 0% | 0% | 3.18% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.1% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 275