AAC(6')-Ia

Accession ARO:3002545
Synonym(s)AAC(6')-I aacA1
CARD Short NameAAC(6')-Ia
DefinitionAAC(6')-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Citrobacter diversus, E. coli, K. pneumoniae, Shigella sonnei, and P. aeruginosa.
AMR Gene FamilyAAC(6')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAeromonas caviaep, Aeromonas veroniip, Enterobacter cloacaep+wgs, Klebsiella pneumoniaep+wgs, Providencia rettgeriwgs
Resistomes with Sequence VariantsAeromonas caviaep, Aeromonas veroniip, Enterobacter cloacaep+wgs, Enterobacter hormaecheiwgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs
Classification9 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic amikacin [Antibiotic]
+ confers_resistance_to_antibiotic kanamycin A [Antibiotic]
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
+ AAC(6') [AMR Gene Family]
Publications

Tenover FC, et al. 1988. J Bacteriol 170(1): 471-473. Cloning and sequencing of a gene encoding an aminoglycoside 6'-N-acetyltransferase from an R factor of Citrobacter diversus. (PMID 2826403)

Parent R and Roy PH. 1992. J Bacteriol 174(9): 2891-2897. The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat. (PMID 1314803)

Resistomes

Prevalence of AAC(6')-Ia among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Aeromonas caviae0%4.08%0%0%
Aeromonas veronii0%2.33%0%0%
Enterobacter cloacae0%1.88%0.36%0%
Enterobacter hormaechei0%0%0.09%0%
Escherichia coli0%0%0%0%
Klebsiella pneumoniae0%0.01%0.02%0%
Klebsiella quasipneumoniae0%0%0.33%0%
Providencia rettgeri0%0%3.68%0%
Pseudomonas aeruginosa0%0%0.02%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 275


>gb|AAA98298.1|+|AAC(6')-Ia [Plasmid R]
MNYQIVNIAECSNYQLEAANILTEAFNDLGNNSWPDMTSATKEVKECIESPNLCFGLLINNSLVGWIGLRPMYKETWELHPLVVRPDYQN
KGIGKILLKELENRAREQGIIGIALGTDDEYYRTSLSLITITEDNIFDSIKNIKNINKHPYEFYQKNGYYIVGIIPNANGKNKPDIWMWK
SLIKE


>gb|M18967.1|+|757-1314|AAC(6')-Ia [Plasmid R]
ATGAATTATCAAATTGTGAATATTGCGGAATGCAGCAATTATCAGTTAGAAGCAGCAAATATACTAACAGAAGCGTTCAATGATCTTGGT
AACAATTCATGGCCAGATATGACGAGTGCAACAAAAGAAGTAAAAGAATGTATTGAGAGTCCAAACCTTTGTTTCGGTCTGCTAATAAAT
AACTCCTTAGTTGGCTGGATAGGCTTAAGGCCAATGTACAAGGAAACCTGGGAATTGCATCCATTGGTTGTCAGACCAGATTATCAAAAT
AAAGGTATTGGCAAGATCCTGCTTAAGGAATTAGAAAACAGAGCTAGAGAGCAAGGTATTATTGGAATCGCTTTAGGAACAGATGATGAA
TACTATAGAACAAGTCTCTCTTTAATAACTATAACAGAAGATAATATATTTGATTCAATAAAAAATATTAAAAATATTAATAAACATCCA
TATGAGTTTTATCAGAAGAATGGTTATTATATTGTTGGAATAATTCCAAATGCCAATGGTAAAAACAAACCAGATATTTGGATGTGGAAA
AGTTTAATCAAAGAGTAA