AAC(6')-I33

Accession ARO:3002587
CARD Short NameAAC(6')-I33
DefinitionAAC(6')-I33 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa.
AMR Gene FamilyAAC(6')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniiwgs, Enterobacter cloacaep, Escherichia colip, Klebsiella pneumoniaep+wgs, Pseudomonas aeruginosawgs
Resistomes with Sequence VariantsAcinetobacter baumanniiwgs, Enterobacter cloacaep, Escherichia colip, Klebsiella pneumoniaep+wgs, Pseudomonas aeruginosawgs
Classification10 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ AAC(6') [AMR Gene Family]
+ confers_resistance_to_antibiotic amikacin [Antibiotic]
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
Publications

Viedma E, et al. 2009. Antimicrob Agents Chemother 53(11): 4930-4933. Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain. (PMID 19738007)

Resistomes

Prevalence of AAC(6')-I33 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0%0%0.01%0%
Enterobacter cloacae0%0.56%0%0%
Escherichia coli0%0.01%0%0%
Klebsiella pneumoniae0%0.06%0.07%0%
Pseudomonas aeruginosa0%0%0.17%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 275


>gb|AEZ05106.1|+|AAC(6')-I33 [Escherichia coli]
MAYEFCEIGESNEYIILAARILTKSFLDIGNNSWPDMKSATKEVEECIEKPNICLGIHENEKLLGWIGLRPMYKLTWELHPLVISTQYQN
KGIGRLLINELEKKAKQIGIIGIVLGTDDEYFKTSLSAVDLYGENILDEIRTIKNIKNHPYEFYQKCGYSIVGVIPDANGKRKPDIWMWK
KIND


>gb|JN596280.1|+|1203-1757|AAC(6')-I33 [Escherichia coli]
ATGGCGTATGAGTTCTGCGAAATAGGTGAATCAAACGAATATATTATTCTGGCGGCTAGAATCTTAACGAAATCATTCCTAGATATCGGT
AATAATTCCTGGCCTGACATGAAAAGTGCTACTAAAGAAGTTGAAGAATGCATTGAGAAGCCAAACATATGTCTTGGAATACATGAAAAT
GAAAAATTGCTTGGATGGATTGGCCTTAGGCCCATGTACAAATTAACATGGGAATTACATCCCTTGGTAATAAGTACTCAATATCAGAAT
AAAGGTATTGGAAGACTTTTAATAAATGAATTAGAAAAAAAAGCAAAGCAAATTGGAATAATTGGAATAGTATTGGGAACTGACGATGAA
TACTTTAAAACTTCATTATCAGCTGTTGATCTTTACGGCGAAAATATTCTTGATGAGATAAGGACTATTAAAAACATAAAAAATCATCCG
TACGAATTCTATCAAAAATGTGGGTATTCCATTGTCGGAGTAATACCCGATGCAAATGGAAAAAGGAAGCCAGATATTTGGATGTGGAAG
AAGATAAATGATTAG