AAC(6')-Iai

Accession ARO:3002575
DefinitionAAC(6')-Iai is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa
AMR Gene FamilyAAC(6')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsPseudomonas aeruginosawgs
Classification19 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ AAC(6') [AMR Gene Family]
Resistomes

Prevalence of AAC(6')-Iai among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 88 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Pseudomonas aeruginosa0%0%0.02%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 275


>gb|ACI28880.1|+|AAC(6')-Iai [Pseudomonas aeruginosa]
MKYTIIDIKDSETYITQAAEILFDVFSEISPESWPTLQKAKEDVIECIEGENICIGIIINKELIGWIGLREMYKKTWELHPMVIKKTHHN
MGFGKILINEIEKKARERNLEGIVLGTDDETYRTSLSMIELNNENILQEIKNIRNLENHPYEFYKKCGYCIIGVIPNANGKNKPDILMWK
NIMEENCG


>gb|EU886977|+|544-1110|AAC(6')-Iai [Pseudomonas aeruginosa]
ATGAAATACACTATTATTGATATTAAAGATTCAGAAACGTACATTACTCAAGCTGCAGAAATATTATTTGATGTATTTTCAGAAATAAGC
CCAGAATCATGGCCAACACTCCAAAAAGCAAAAGAAGATGTTATTGAATGTATAGAAGGTGAAAACATTTGCATTGGCATTATAATAAAT
AAAGAATTAATTGGATGGATTGGATTAAGAGAAATGTATAAAAAAACATGGGAATTACATCCTATGGTTATCAAGAAAACACATCATAAT
ATGGGATTTGGAAAAATACTAATTAATGAAATAGAAAAAAAAGCAAGAGAAAGAAATTTAGAAGGTATTGTACTTGGAACAGATGATGAA
ACATATAGAACTTCATTATCAATGATTGAATTAAATAATGAAAATATTTTGCAAGAAATAAAGAATATTAGAAATTTAGAAAATCATCCT
TATGAATTTTATAAAAAATGTGGATATTGTATTATTGGTGTAATTCCAAACGCAAATGGGAAGAATAAGCCAGATATATTAATGTGGAAA
AATATTATGGAAGAAAATTGCGGCTAA