| Accession | ARO:3002623 |
| Synonym(s) | aadD1 |
| CARD Short Name | ANT(4')-Ia |
| Definition | ANT(4')-Ia is a plasmid-encoded aminoglycoside nucleotidyltransferase in S. epidermidis, S. aureus, Enterococcus spp. and Bacillus spp. |
| AMR Gene Family | ANT(4') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Aliarcobacter butzlerig, Bacillus subtilisg+wgs, Bacillus thuringiensisp+wgs, Bacillus velezensiswgs, Enterococcus faecalisp+wgs, Enterococcus faeciumwgs, Escherichia colip+wgs, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaep, Providencia alcalifacienswgs, Pseudomonas aeruginosawgs, Staphylococcus arlettaep+wgs, Staphylococcus aureusg+p+wgs, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+p+wgs, Staphylococcus haemolyticusg+p+wgs, Staphylococcus hominisg+p+wgs, Staphylococcus lugdunensisp, Staphylococcus pasteuriwgs, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticuswgs, Staphylococcus schleiferig, Staphylococcus warnerip+wgs, Streptococcus suiswgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + nucleotidylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside nucleotidyltransferase (ANT) + aminoglycoside antibiotic [Drug Class] + ANT(4') [AMR Gene Family] |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic isepamicin [Antibiotic] + ANT(4')-I |
| Publications | Santanam P and Kayser FH. 1978. J Antibiot (Tokyo) 31(4): 343-351. Purification and characterization of an aminoglycoside inactivating enzyme from Staphylococcus epidermidis FK109 that nucleotidylates the 4'- and 4''-hydroxyl groups of the aminoglycoside antibiotics. (PMID 659332) McKenzie T, et al. 1986. Plasmid 15(2): 93-103. The nucleotide sequence of pUB110: some salient features in relation to replication and its regulation. (PMID 3010356) |
Prevalence of ANT(4')-Ia among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aliarcobacter butzleri | 12.5% | 0% | 0% | 0% |
| Bacillus subtilis | 5.38% | 0% | 0.29% | 0% |
| Bacillus thuringiensis | 0% | 0.39% | 0.35% | 0% |
| Bacillus velezensis | 0% | 0% | 0.73% | 0% |
| Enterococcus faecalis | 0% | 1.23% | 0.74% | 0% |
| Enterococcus faecium | 0% | 0% | 0.24% | 0% |
| Escherichia coli | 0% | 0.01% | 0.01% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 0% | 0% |
| Providencia alcalifaciens | 0% | 0% | 3.45% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.03% | 0% |
| Staphylococcus arlettae | 0% | 8.33% | 2.5% | 0% |
| Staphylococcus aureus | 8.46% | 4.35% | 10.12% | 0% |
| Staphylococcus capitis | 30% | 0% | 13.29% | 0% |
| Staphylococcus epidermidis | 5.81% | 2.59% | 17.74% | 0% |
| Staphylococcus haemolyticus | 10.34% | 1.89% | 11.21% | 0% |
| Staphylococcus hominis | 6.25% | 2.08% | 14.15% | 0% |
| Staphylococcus lugdunensis | 0% | 3.57% | 0% | 0% |
| Staphylococcus pasteuri | 0% | 0% | 3.85% | 0% |
| Staphylococcus pseudintermedius | 0% | 0% | 0.26% | 0% |
| Staphylococcus saprophyticus | 0% | 0% | 0.7% | 0% |
| Staphylococcus schleiferi | 18.18% | 0% | 0% | 0% |
| Staphylococcus warneri | 0% | 7.5% | 4.92% | 0% |
| Streptococcus suis | 0% | 0% | 1.21% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500