AAC(6')-Ian

Accession ARO:3003200
DefinitionAAC(6')-Ian is an amikacin acetyltransferase gene found on a transferable plasmid of the Serratia marcescens strain NUBL-11663. It catalyzes the transfer of an acetyl group from acetyl coenzyme A onto an amine at the 6'-position of various aminoglycosides.
AMR Gene FamilyAAC(6')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniig+p+wgs, Enterobacter asburiaewgs, Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella pneumoniaep+wgs
Resistomes with Sequence VariantsAcinetobacter baumanniig+p+wgs, Enterobacter asburiaewgs, Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella pneumoniaep+wgs
Classification19 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ AAC(6') [AMR Gene Family]
Publications

Jin W, et al. 2015. J Antimicrob Chemother 70(5): 1331-1337. New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate. (PMID 25576529)

Resistomes

Prevalence of AAC(6')-Ian among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 88 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Acinetobacter baumannii5.98%0.71%5.47%
Enterobacter asburiae0%0%1.19%
Enterobacter hormaechei0%0%0.12%
Escherichia coli0%0.01%0.01%
Klebsiella pneumoniae0%0.02%0.17%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 330


>gb|BAQ22025.1|-|AAC(6')-Ian [Serratia marcescens]
MLVQQGRLAIRALQKSDAPVMLRWLQDERVLEFYEGRDKHFDLQTVIEVFIEDQGETTPCLVLLDDKPLGYVQFYPLDSEDKQALELPVE
DVIYGLDQFIGEPDFWGLGLGTELVSLVRDYLITDKAAQRLVLDPQSRNSRAIACYEKCGFEKLRLLPAHEMHEGQLQDCWLMQYYPARS
SLMASSRPKI


>gb|AP014611|-|26118-26690|AAC(6')-Ian [Serratia marcescens]
ATGCTGGTGCAGCAAGGCAGATTGGCAATACGTGCATTACAGAAAAGCGATGCGCCGGTGATGCTGCGCTGGCTGCAGGATGAGCGGGTG
CTGGAATTTTACGAAGGGCGTGACAAACACTTCGATCTGCAAACGGTCATTGAAGTTTTTATCGAGGATCAGGGGGAAACCACACCGTGT
CTGGTGTTACTGGATGATAAACCGCTTGGTTATGTGCAGTTCTACCCGCTGGATAGCGAAGATAAACAGGCGCTGGAACTACCGGTTGAG
GATGTGATCTACGGGCTGGATCAGTTTATCGGCGAACCGGATTTCTGGGGGCTGGGACTTGGTACTGAGCTTGTCTCGCTGGTGCGCGAT
TATCTCATAACAGACAAGGCCGCACAGCGCCTTGTTCTCGACCCGCAAAGCCGCAACTCACGCGCAATTGCCTGCTATGAAAAATGCGGC
TTTGAAAAACTCCGCTTGCTGCCCGCCCATGAAATGCATGAAGGGCAGCTGCAAGATTGCTGGCTGATGCAGTATTATCCCGCGCGCAGC
AGTCTGATGGCTTCGTCACGCCCGAAAATATAG