| Accession | ARO:3003200 |
| CARD Short Name | AAC(6')-Ian |
| Definition | AAC(6')-Ian is an amikacin acetyltransferase gene found on a transferable plasmid of the Serratia marcescens strain NUBL-11663. It catalyzes the transfer of an acetyl group from acetyl coenzyme A onto an amine at the 6'-position of various aminoglycosides. |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniig+p+wgs, Citrobacter freundiiwgs, Enterobacter asburiaewgs, Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Proteus mirabilisp, Serratia marcescenswgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs, Citrobacter freundiiwgs, Enterobacter asburiaewgs, Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Proteus mirabilisp, Serratia marcescenswgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + antibiotic molecule + acylation of antibiotic conferring resistance + aminoglycoside modifying enzyme + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + AAC(6') [AMR Gene Family] |
| Parent Term(s) | 8 ontology terms | Show + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic 2'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic 5-episisomicin [Antibiotic] + confers_resistance_to_antibiotic sisomicin [Antibiotic] + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + AAC(6')-I |
| Publications | Jin W, et al. 2015. J Antimicrob Chemother 70(5): 1331-1337. New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate. (PMID 25576529) |
Prevalence of AAC(6')-Ian among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 2.65% | 0.36% | 3.94% | 0% |
| Citrobacter freundii | 0% | 0% | 0.58% | 0% |
| Enterobacter asburiae | 0% | 0% | 0.4% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.13% | 0% |
| Escherichia coli | 0% | 0.01% | 0.01% | 0% |
| Klebsiella pneumoniae | 0% | 0.01% | 0.09% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.39% | 0% |
| Proteus mirabilis | 0% | 1.25% | 0% | 0% |
| Serratia marcescens | 0% | 0% | 0.13% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 330