AAC(6')-Ii

Accession ARO:3002556
DefinitionAAC(6')-Ii is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus spp.
AMR Gene FamilyAAC(6')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesEnterococcus faeciumwgs
Resistomes with Sequence VariantsAcinetobacter baumanniiwgs, Enterococcus faecaliswgs, Enterococcus faeciumg+wgs, Listeria monocytogeneswgs
Classification19 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ AAC(6') [AMR Gene Family]
+ confers_resistance_to_antibiotic plazomicin [Antibiotic]
Publications

Costa Y, et al. 1993. Antimicrob Agents Chemother 37(9): 1896-1903. Characterization of the chromosomal aac(6')-Ii gene specific for Enterococcus faecium. (PMID 8239603)

Wybenga-Groot LE, et al. 1999. Structure 7(5): 497-507. Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold. (PMID 10378269)

Draker KA, et al. 2003. Biochemistry 42(21): 6565-6574. Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity. (PMID 12767240)

Resistomes

Prevalence of AAC(6')-Ii among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 88 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Acinetobacter baumannii0%0%0.02%
Enterococcus faecalis0%0%0.25%
Enterococcus faecium99.34%0%90.85%
Klebsiella oxytoca0%0%0%
Listeria monocytogenes0%0%0.03%
Proteus mirabilis0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 275


>gb|AAB63533.1|+|AAC(6')-Ii [Enterococcus faecium]
MIISEFDRNNPVLKDQLSDLLRLTWPEEYGDSSAEEVEEMMNPERIAVAAVDQDELVGFIGAIPQYGITGWELHPLVVESSRRKNQIGTR
LVNYLEKEVASRGGITIYLGTDDLDHGTTLSQTDLYVHTFDKVASIQNLREHPYEFYEKLGYKIVGVLPNANGWDKPDIWMAKTIIPRPD
SQ


>gb|L12710|+|1-549|AAC(6')-Ii [Enterococcus faecium]
ATGATAATCAGTGAATTTGACCGTAATAATCCAGTATTGAAAGATCAGCTTTCTGATTTACTGAGACTGACTTGGCCGGAAGAATATGGA
GACAGCTCGGCAGAAGAAGTAGAAGAAATGATGAATCCAGAACGAATCGCGGTAGCAGCGGTAGACCAAGATGAGTTAGTAGGATTTATT
GGTGCAATCCCTCAATACGGTATCACAGGTTGGGAATTGCATCCATTAGTTGTAGAAAGCTCCCGACGAAAGAACCAAATAGGTACTCGA
TTAGTCAATTACTTAGAAAAAGAAGTAGCTTCCAGAGGAGGAATCACGATTTATTTAGGTACGGATGATTTAGACCATGGAACAACGTTA
AGTCAAACGGACCTGTATGTGCATACATTTGATAAAGTGGCTTCCATCCAGAACCTTCGTGAACATCCGTATGAATTCTATGAAAAATTA
GGTTATAAAATCGTAGGTGTCTTACCAAATGCAAATGGCTGGGACAAACCGGATATTTGGATGGCAAAAACGATTATTCCTCGACCAGAT
TCTCAATAA