| Accession | ARO:3004629 |
| Definition | AAC(6')-Im is an aminoglycoside acetyltransferase encoded by plasmids in E. coli, and E. faecium |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Campylobacter colip, Clostridioides difficilewgs, Enterobacter hormaecheiwgs, Enterococcus faecaliswgs, Enterococcus faeciump+wgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosawgs, Salmonella entericawgs |
| Resistomes with Sequence Variants | Campylobacter colip+wgs, Campylobacter jejuniwgs, Clostridioides difficilewgs, Enterobacter hormaecheiwgs, Enterococcus faecaliswgs, Enterococcus faeciump+wgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosawgs, Salmonella entericawgs |
| Classification | 19 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + aminoglycoside antibiotic [Drug Class] + acylation of antibiotic conferring resistance + antibiotic inactivation enzyme + isepamicin [Antibiotic] + arbekacin [Antibiotic] + sisomicin [Antibiotic] + gentamicin B [Antibiotic] + aminoglycoside acetyltransferase (AAC) + tobramycin [Antibiotic] + dibekacin [Antibiotic] + kanamycin A [Antibiotic] + netilmicin [Antibiotic] + amikacin [Antibiotic] + neomycin [Antibiotic] |
| Parent Term(s) | 6 ontology terms | Show + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + AAC(6') [AMR Gene Family] |
| Publications | Chow JW, et al. 2001. Antimicrob Agents Chemother 45(10): 2691-2694. Aminoglycoside resistance genes aph(2)-Ib and aac(6')-Im detected together in strains of both Escherichia coli and Enterococcus faecium. (PMID 11557456) |
Prevalence of AAC(6')-Im among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 88 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS |
|---|---|---|---|
| Campylobacter coli | 0% | 1.49% | 0.22% |
| Campylobacter jejuni | 0% | 0% | 0.07% |
| Clostridioides difficile | 0% | 0% | 0.16% |
| Enterobacter hormaechei | 0% | 0% | 0.37% |
| Enterococcus faecalis | 0% | 0% | 0.08% |
| Enterococcus faecium | 0% | 0.15% | 0.12% |
| Klebsiella pneumoniae | 0% | 0% | 0.3% |
| Pseudomonas aeruginosa | 0% | 0% | 0.02% |
| Salmonella enterica | 0% | 0% | 0.01% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 275