| Accession | ARO:3002596 |
| CARD Short Name | AAC(6')-IIc |
| Definition | AAC(6')-IIc is an aminoglycoside acetyltransferase encoded by plasmids and integrons in E. cloacae. |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Aeromonas veroniip, Citrobacter amalonaticuswgs, Citrobacter freundiiwgs, Citrobacter portucalensisp, Citrobacter youngaewgs, Cronobacter malonaticuswgs, Enterobacter asburiaeg+p+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia coliwgs, Klebsiella aerogeneswgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaewgs, Proteus mirabiliswgs, Providencia stuartiip, Pseudomonas aeruginosawgs, Pseudomonas chlororaphiswgs, Pseudomonas putidawgs, Salmonella entericawgs, Serratia marcescensp+wgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Aeromonas veroniip, Citrobacter amalonaticuswgs, Citrobacter freundiiwgs, Citrobacter portucalensisp, Citrobacter youngaewgs, Comamonas testosteronip, Cronobacter malonaticuswgs, Enterobacter asburiaeg+p+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia coliwgs, Klebsiella aerogeneswgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaewgs, Proteus mirabiliswgs, Providencia stuartiip, Pseudomonas aeruginosawgs, Pseudomonas chlororaphiswgs, Pseudomonas putidawgs, Salmonella entericawgs, Serratia marcescensp+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + acylation of antibiotic conferring resistance + aminoglycoside modifying enzyme + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + antibiotic mixture + AAC(6') [AMR Gene Family] |
| Parent Term(s) | 8 ontology terms | Show + confers_resistance_to_antibiotic 5-episisomicin [Antibiotic] + confers_resistance_to_antibiotic gentamicin [Antibiotic] + confers_resistance_to_antibiotic 2'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic sisomicin [Antibiotic] + AAC(6')-II |
| Publications | Galani I, et al. 2005. J Antimicrob Chemother 55(5): 634-638. Characterization of a new integron containing bla(VIM-1) and aac(6')-IIc in an Enterobacter cloacae clinical isolate from Greece. (PMID 15761066) |
Prevalence of AAC(6')-IIc among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.07% | 0% |
| Aeromonas veronii | 0% | 2.33% | 0% | 0% |
| Citrobacter amalonaticus | 0% | 0% | 2.08% | 0% |
| Citrobacter freundii | 0% | 0% | 2.14% | 0% |
| Citrobacter portucalensis | 0% | 1.52% | 0% | 0% |
| Citrobacter youngae | 0% | 0% | 6.25% | 0% |
| Comamonas testosteroni | 0% | 50% | 0% | 0% |
| Cronobacter malonaticus | 0% | 0% | 1.82% | 0% |
| Enterobacter asburiae | 7.69% | 3.64% | 8.44% | 0% |
| Enterobacter chengduensis | 0% | 0% | 14.29% | 0% |
| Enterobacter cloacae | 0% | 1.25% | 6.12% | 0% |
| Enterobacter hormaechei | 0.85% | 9.63% | 12.07% | 0% |
| Enterobacter kobei | 0% | 0% | 6.7% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 0.81% | 0% |
| Escherichia coli | 0% | 0% | 0.04% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.62% | 0% |
| Klebsiella michiganensis | 0% | 0.74% | 0.3% | 0% |
| Klebsiella oxytoca | 0% | 0% | 0.98% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.33% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.33% | 0% |
| Proteus mirabilis | 0% | 0% | 0.8% | 0% |
| Providencia stuartii | 0% | 3.57% | 0% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.21% | 0% |
| Pseudomonas chlororaphis | 0% | 0% | 2.33% | 0% |
| Pseudomonas putida | 0% | 0% | 0.68% | 0% |
| Salmonella enterica | 0% | 0% | 0.05% | 0% |
| Serratia marcescens | 0% | 1.32% | 0.41% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 275