| Accession | ARO:3002535 |
| Synonym(s) | aacC2 |
| CARD Short Name | AAC(3)-IIc |
| Definition | AAC(3)-IIc is a plasmid-encoded aminoglycoside acetyltransferase in E. coli and P. aeruginosa. |
| AMR Gene Family | AAC(3) |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter baumanniip+wgs+gi, Acinetobacter indicusp, Acinetobacter johnsoniip, Acinetobacter juniip, Acinetobacter pittiip, Acinetobacter townerip, Aeromonas caviaep, Brucella intermediawgs, Citrobacter freundiip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Enterobacter asburiaewgs, Enterobacter hormaecheiwgs+gi, Escherichia colig+p+wgs+gi, Escherichia fergusoniip, Klebsiella aerogenesp, Klebsiella oxytocap+wgs, Klebsiella pneumoniaep+wgs+gi, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs+gi, Paracoccus denitrificanswgs, Proteus mirabiliswgs+gi, Pseudomonas aeruginosawgs, Salmonella entericap+wgs, Serratia marcescenswgs, Shigella flexnerip, Shigella sonneiwgs, Stenotrophomonas maltophiliawgs, Vibrio choleraep+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + antibiotic mixture + AAC(3) [AMR Gene Family] |
| Parent Term(s) | 8 ontology terms | Show + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic sisomicin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic 6'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic 2'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic gentamicin [Antibiotic] + AAC(3)-II |
| Publications | Dubois V, et al. 2008. J Antimicrob Chemother 62(2): 316-323. Beta-lactam and aminoglycoside resistance rates and mechanisms among Pseudomonas aeruginosa in French general practice (community and private healthcare centres). (PMID 18467306) Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262) |
Prevalence of AAC(3)-IIc among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0.47% | 0.26% | 1.89% |
| Acinetobacter indicus | 0% | 3.77% | 0% | 0% |
| Acinetobacter johnsonii | 0% | 1.39% | 0% | 0% |
| Acinetobacter junii | 0% | 16.67% | 0% | 0% |
| Acinetobacter pittii | 0% | 0.99% | 0% | 0% |
| Acinetobacter towneri | 0% | 12.5% | 0% | 0% |
| Aeromonas caviae | 0% | 1.3% | 0% | 0% |
| Brucella intermedia | 0% | 0% | 5.41% | 0% |
| Citrobacter freundii | 0% | 0.62% | 1.55% | 0% |
| Citrobacter portucalensis | 0% | 1.47% | 0.9% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Citrobacter youngae | 0% | 0% | 6.25% | 0% |
| Enterobacter asburiae | 0% | 0% | 0.4% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.52% | 6.67% |
| Escherichia coli | 0.12% | 0.13% | 0.31% | 0.89% |
| Escherichia fergusonii | 0% | 0.36% | 0% | 0% |
| Klebsiella aerogenes | 0% | 2.17% | 0% | 0% |
| Klebsiella oxytoca | 0% | 0.68% | 0.42% | 0% |
| Klebsiella pneumoniae | 0% | 0.23% | 0.77% | 1.9% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.66% | 0% |
| Morganella morganii | 0% | 0% | 0.61% | 7.69% |
| Paracoccus denitrificans | 0% | 0% | 16.67% | 0% |
| Proteus mirabilis | 0% | 0% | 0.33% | 7.41% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Salmonella enterica | 0% | 0.16% | 0.03% | 0% |
| Serratia marcescens | 0% | 0% | 0.13% | 0% |
| Shigella flexneri | 0% | 0.8% | 0% | 0% |
| Shigella sonnei | 0% | 0% | 0.07% | 0% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.89% | 0% |
| Vibrio cholerae | 0% | 5.26% | 0.13% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300