| Accession | ARO:3002594 |
| CARD Short Name | AAC(6')-IIa |
| Definition | AAC(6')-IIa is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa and S. enterica. |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Actinobacillus pleuropneumoniaeg, Aeromonas caviaeg, Aeromonas hydrophilap, Aeromonas veroniig, Alcaligenes faecalisg, Escherichia colip, Klebsiella michiganensisg, Klebsiella pneumoniaeg, Pseudomonas aeruginosap, Pseudomonas mendocinag+p, Pseudomonas monteiliig, Pseudomonas putidag, Pseudomonas stutzerig |
| Resistomes with Sequence Variants | Actinobacillus pleuropneumoniaeg, Aeromonas caviaeg+p, Aeromonas hydrophilap, Aeromonas veroniig, Alcaligenes faecalisg, Burkholderia cenocepaciag, Escherichia colip, Klebsiella michiganensisg, Klebsiella pneumoniaeg, Pseudomonas aeruginosap, Pseudomonas mendocinag+p, Pseudomonas monteiliig, Pseudomonas putidag, Pseudomonas stutzerig |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + acylation of antibiotic conferring resistance + aminoglycoside modifying enzyme + antibiotic molecule + aminoglycoside antibiotic [Drug Class] + aminoglycoside acetyltransferase (AAC) + AAC(6') [AMR Gene Family] + antibiotic mixture |
| Parent Term(s) | 8 ontology terms | Show + confers_resistance_to_antibiotic gentamicin [Antibiotic] + confers_resistance_to_antibiotic 5-episisomicin [Antibiotic] + confers_resistance_to_antibiotic 2'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic sisomicin [Antibiotic] + AAC(6')-II |
| Publications | Shaw KJ, et al. 1989. Antimicrob Agents Chemother 33(12): 2052-2062. Isolation, characterization, and DNA sequence analysis of an AAC(6')-II gene from Pseudomonas aeruginosa. (PMID 2515793) |
Prevalence of AAC(6')-IIa among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 381 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Actinobacillus pleuropneumoniae | 2.78% | 0% | 0% | 0% |
| Aeromonas caviae | 4.55% | 1.3% | 0% | 0% |
| Aeromonas hydrophila | 0% | 1.3% | 0% | 0% |
| Aeromonas veronii | 1.82% | 0% | 0% | 0% |
| Alcaligenes faecalis | 5% | 0% | 0% | 0% |
| Burkholderia cenocepacia | 0.5% | 0% | 0% | 0% |
| Escherichia coli | 0% | 0.01% | 0% | 0% |
| Klebsiella michiganensis | 1.61% | 0% | 0% | 0% |
| Klebsiella pneumoniae | 0.12% | 0% | 0% | 0% |
| Pseudomonas aeruginosa | 0% | 2.05% | 0% | 0% |
| Pseudomonas mendocina | 12.5% | 50% | 0% | 0% |
| Pseudomonas monteilii | 22.22% | 0% | 0% | 0% |
| Pseudomonas putida | 2.82% | 0% | 0% | 0% |
| Pseudomonas stutzeri | 7.14% | 0% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 275