| Accession | ARO:3002594 |
| CARD Short Name | AAC(6')-IIa |
| Definition | AAC(6')-IIa is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa and S. enterica. |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Achromobacter xylosoxidanswgs, Acinetobacter pittiiwgs, Actinobacillus pleuropneumoniaeg, Aeromonas caviaeg+wgs, Aeromonas hydrophilap, Aeromonas veroniig+wgs, Alcaligenes faecalisg+gi, Bordetella trematumgi, Citrobacter freundiiwgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Escherichia colip, Klebsiella michiganensisg+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+wgs, Laribacter hongkongensiswgs, Leclercia adecarboxylatawgs, Proteus mirabiliswgs, Pseudomonas aeruginosap+wgs, Pseudomonas mendocinag+p, Pseudomonas monteiliig+gi, Pseudomonas putidag+wgs, Pseudomonas stutzerig, Stenotrophomonas maltophiliawgs, Vibrio choleraewgs |
| Resistomes with Sequence Variants | Achromobacter xylosoxidanswgs, Acinetobacter baumanniiwgs, Acinetobacter pittiiwgs, Actinobacillus pleuropneumoniaeg, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilap, Aeromonas veroniig+wgs, Alcaligenes faecalisg+gi, Bordetella trematumgi, Burkholderia cenocepaciag, Burkholderia cepaciawgs, Burkholderia vietnamiensiswgs, Citrobacter freundiiwgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia colip, Klebsiella michiganensisg+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+wgs, Laribacter hongkongensiswgs, Leclercia adecarboxylatawgs, Proteus mirabiliswgs, Pseudomonas aeruginosap+wgs, Pseudomonas mendocinag+p, Pseudomonas monteiliig+gi, Pseudomonas putidag+wgs, Pseudomonas stutzerig, Serratia marcescenswgs, Stenotrophomonas maltophiliawgs, Vibrio alginolyticuswgs, Vibrio choleraewgs, Vibrio parahaemolyticuswgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + antibiotic molecule + acylation of antibiotic conferring resistance + aminoglycoside modifying enzyme + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + AAC(6') [AMR Gene Family] + antibiotic mixture |
| Parent Term(s) | 8 ontology terms | Show + confers_resistance_to_antibiotic gentamicin [Antibiotic] + confers_resistance_to_antibiotic 5-episisomicin [Antibiotic] + confers_resistance_to_antibiotic 2'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic sisomicin [Antibiotic] + AAC(6')-II |
| Publications | Shaw KJ, et al. 1989. Antimicrob Agents Chemother 33(12): 2052-2062. Isolation, characterization, and DNA sequence analysis of an AAC(6')-II gene from Pseudomonas aeruginosa. (PMID 2515793) |
Prevalence of AAC(6')-IIa among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Achromobacter xylosoxidans | 0% | 0% | 0.76% | 0% |
| Acinetobacter baumannii | 0% | 0% | 0.03% | 0% |
| Acinetobacter pittii | 0% | 0% | 0.28% | 0% |
| Actinobacillus pleuropneumoniae | 2.78% | 0% | 0% | 0% |
| Aeromonas caviae | 4.55% | 1.3% | 6.99% | 0% |
| Aeromonas hydrophila | 0% | 1.3% | 0% | 0% |
| Aeromonas veronii | 1.82% | 0% | 1.69% | 0% |
| Alcaligenes faecalis | 5% | 0% | 0% | 33.33% |
| Bordetella trematum | 0% | 0% | 0% | 50% |
| Burkholderia cenocepacia | 0.5% | 0% | 0% | 0% |
| Burkholderia cepacia | 0% | 0% | 0.45% | 0% |
| Burkholderia vietnamiensis | 0% | 0% | 0.86% | 0% |
| Citrobacter freundii | 0% | 0% | 0.19% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.22% | 0% |
| Enterobacter kobei | 0% | 0% | 1.75% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 0.72% | 0% |
| Escherichia coli | 0% | 0.01% | 0% | 0% |
| Klebsiella michiganensis | 1.61% | 0% | 0.8% | 0% |
| Klebsiella oxytoca | 0% | 0% | 1.26% | 0% |
| Klebsiella pneumoniae | 0.12% | 0% | 0.03% | 0% |
| Laribacter hongkongensis | 0% | 0% | 2.08% | 0% |
| Leclercia adecarboxylata | 0% | 0% | 2.33% | 0% |
| Proteus mirabilis | 0% | 0% | 0.33% | 0% |
| Pseudomonas aeruginosa | 0% | 2.05% | 0.41% | 0% |
| Pseudomonas mendocina | 12.5% | 50% | 0% | 0% |
| Pseudomonas monteilii | 22.22% | 0% | 0% | 100% |
| Pseudomonas putida | 2.82% | 0% | 2.67% | 0% |
| Pseudomonas stutzeri | 7.14% | 0% | 0% | 0% |
| Serratia marcescens | 0% | 0% | 0.26% | 0% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.15% | 0% |
| Vibrio alginolyticus | 0% | 0% | 0.79% | 0% |
| Vibrio cholerae | 0% | 0% | 0.13% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.31% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 275