| Accession | ARO:3002533 |
| Synonym(s) | aaC3 aac(3)-Va aacC2 aacC5 |
| CARD Short Name | AAC(3)-IIa |
| Definition | AAC(3)-IIa is a plasmid-encoded aminoglycoside acetyltransferase in K. pneumoniae, E. cloacae, Actinobacillus pleuropneumoniae, S. typhimurium, Citrobacter freundii, and P. aeruginosa. |
| AMR Gene Family | AAC(3) |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter indicusgi, Actinobacillus indolicusgi, Citrobacter freundiigi, Escherichia coligi, Klebsiella huaxiensisgi, Klebsiella pneumoniaegi, Morganella morganiigi, Proteus mirabilisgi, Pseudomonas aeruginosawgs+gi, Salmonella entericagi, Serratia marcescensgi |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + antibiotic mixture + AAC(3) [AMR Gene Family] |
| Parent Term(s) | 8 ontology terms | Show + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic sisomicin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic 6'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic 2'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic gentamicin [Antibiotic] + AAC(3)-II |
| Publications | Allmansberger R, et al. 1985. Mol Gen Genet 198(3): 514-520. Genes for gentamicin-(3)-N-acetyl-transferases III and IV. II. Nucleotide sequences of three AAC(3)-III genes and evolutionary aspects. (PMID 3892230) Mugnier P, et al. 1996. Antimicrob Agents Chemother 40(11): 2488-2493. A TEM-derived extended-spectrum beta-lactamase in Pseudomonas aeruginosa. (PMID 8913451) Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262) |
Prevalence of AAC(3)-IIa among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter indicus | 0% | 0% | 0% | 50% |
| Actinobacillus indolicus | 0% | 0% | 0% | 100% |
| Citrobacter freundii | 0% | 0% | 0% | 27.27% |
| Escherichia coli | 0% | 0% | 0% | 0.77% |
| Klebsiella huaxiensis | 0% | 0% | 0% | 50% |
| Klebsiella pneumoniae | 0% | 0% | 0% | 6.67% |
| Morganella morganii | 0% | 0% | 0% | 7.69% |
| Proteus mirabilis | 0% | 0% | 0% | 7.41% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 1.39% |
| Salmonella enterica | 0% | 0% | 0% | 0.99% |
| Serratia marcescens | 0% | 0% | 0% | 22.22% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 560