| Accession | ARO:3003211 |
| Definition | Many antibiotics inhibit the growth of bacteria by blocking protein synthesis on the ribosome. The antibiotic-binding sites are located within functionally important structures in the ribosomal RNA. Antibiotic resistance is often conferred by base substitutions or methylations at these sites in the rRNA. Point mutations in the bacterial 16S ribosomal RNA in the small 30S subunit can confer resistance to antibiotics. |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 6 ontology terms | Show |
| Parent Term(s) | 2 ontology terms | Show |
| Sub-Term(s) | 5 ontology terms | Show + 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics [AMR Gene Family] + 16s rRNA with mutation conferring resistance to peptide antibiotics [AMR Gene Family] + 16s rRNA with mutation conferring resistance to polyamine antibiotics [AMR Gene Family] + 16S rRNA with mutation conferring resistance to tetracycline derivatives [AMR Gene Family] + 16S rRNA with mutation conferring resistance to pactamycin [AMR Gene Family] |
| Publications | Poehlsgaard J, et al. 2005. Nat Rev Microbiol 3(11): 870-881. The bacterial ribosome as a target for antibiotics. (PMID 16261170) Yassin A, et al. 2005. Proc Natl Acad Sci U S A 102(46): 16620-16625. Deleterious mutations in small subunit ribosomal RNA identify functional sites and potential targets for antibiotics. (PMID 16269538) Purohit P, et al. 1994. Nature 370(6491): 659-662. Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit. (PMID 8065453) |
| Curator | Description | Most Recent Edit |
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