apramycin [Antibiotic]

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Accession ARO:0000037
Synonym(s)ambylan nebramycin II apralan
DefinitionApramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections in animals. Apramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
5 ontology terms | Show
+ AAC(1)-I confers_resistance_to_antibiotic
+ apmA confers_resistance_to_antibiotic
+ AAC(3)-IV confers_resistance_to_antibiotic
+ kamB confers_resistance_to_antibiotic
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
Publications

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)