streptothricin [Antibiotic]

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Accession ARO:0000012
Synonym(s)streptothricin F racemomycin yazumycin nourseothricin
DefinitionStreptothricins are a group of N-glycoside antibiotics that include a carbamoylated D-glucosamine to which are attached a series of L-beta-lysine residues at position 2 and a streptolidine at position 1. Streptothricins vary by the number of beta-lysine residues (from 1 (nourseothricin) to 7) and target protein synthesis in bacteria and eukaryotes.
Drug Classnucleoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ nucleoside antibiotic [Drug Class]
6 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ SAT-2 confers_resistance_to_antibiotic
+ SAT-4 confers_resistance_to_antibiotic
+ SAT-3 confers_resistance_to_antibiotic
+ sta confers_resistance_to_antibiotic
+ SatA confers_resistance_to_antibiotic

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)