| Accession | ARO:3002630 |
| Synonym(s) | aad(9) aad9 spc spw |
| CARD Short Name | ANT(9)-Ia |
| Definition | ANT(9)-Ia is an aminoglycoside nucleotidyltransferase encoded by plasmids and transposons in S. aureus, Enterococcus spp., Mammaliicoccus sciuri, and E. faecalis. |
| AMR Gene Family | ANT(9) |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Bacillus subtilisg, Bacillus thuringiensiswgs, Bacillus velezensisg, Enterococcus aviumg+wgs, Enterococcus faecalisg+p+wgs, Enterococcus faeciumg+p+wgs, Enterococcus hiraeg+wgs, Leptospira interroganswgs, Staphylococcus aureusg+p+wgs, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+wgs, Staphylococcus haemolyticusg+wgs, Staphylococcus hominiswgs, Staphylococcus lugdunensisg+wgs, Staphylococcus simulansg+wgs, Streptococcus gallolyticuswgs, Streptococcus suiswgs |
| Resistomes with Sequence Variants | Bacillus subtilisg, Bacillus thuringiensiswgs, Bacillus velezensisg, Enterococcus aviumg+wgs, Enterococcus faecalisg+p+wgs, Enterococcus faeciumg+p+wgs, Enterococcus hiraeg+wgs, Leptospira interroganswgs, Staphylococcus aureusg+p+wgs, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+wgs, Staphylococcus haemolyticusg+wgs, Staphylococcus hominiswgs, Staphylococcus lugdunensisg+wgs, Staphylococcus pseudintermediusg, Staphylococcus simulansg+wgs, Streptococcus gallolyticuswgs, Streptococcus suiswgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + nucleotidylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside nucleotidyltransferase (ANT) + aminoglycoside antibiotic [Drug Class] + ANT(9) [AMR Gene Family] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Murphy E, et al. 1985. EMBO J 4(12): 3357-3365. Transposon Tn554: complete nucleotide sequence and isolation of transposition-defective and antibiotic-sensitive mutants. (PMID 3004956) Murphy E. 1985. Mol Gen Genet 200(1): 33-39. Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3) (9). (PMID 2993813) Wendlandt S, et al. 2013. J Antimicrob Chemother 68(7): 1679-1680. Identification of the novel spectinomycin resistance gene spw in methicillin-resistant and methicillin-susceptible Staphylococcus aureus of human and animal origin. (PMID 23511231) |
Prevalence of ANT(9)-Ia among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Bacillus subtilis | 2.15% | 0% | 0% | 0% |
| Bacillus thuringiensis | 0% | 0% | 0.17% | 0% |
| Bacillus velezensis | 0.33% | 0% | 0% | 0% |
| Enterococcus avium | 33.33% | 0% | 15.79% | 0% |
| Enterococcus faecalis | 8.18% | 1.48% | 2.3% | 0% |
| Enterococcus faecium | 3.18% | 0.45% | 5.4% | 0% |
| Enterococcus hirae | 11.54% | 0% | 1.39% | 0% |
| Leptospira interrogans | 0% | 0% | 0.32% | 0% |
| Staphylococcus aureus | 17.1% | 0.26% | 12.86% | 0% |
| Staphylococcus capitis | 30% | 0% | 12.66% | 0% |
| Staphylococcus epidermidis | 6.45% | 0% | 1.84% | 0% |
| Staphylococcus haemolyticus | 3.45% | 0% | 1.98% | 0% |
| Staphylococcus hominis | 0% | 0% | 0.98% | 0% |
| Staphylococcus lugdunensis | 5.56% | 0% | 1.54% | 0% |
| Staphylococcus pseudintermedius | 3.33% | 0% | 0% | 0% |
| Staphylococcus simulans | 5% | 0% | 6.78% | 0% |
| Streptococcus gallolyticus | 0% | 0% | 2.27% | 0% |
| Streptococcus suis | 0% | 0% | 0.16% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 450