aadA11

Accession ARO:3002611
CARD Short NameaadA11
DefinitionaadA11 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli and P. aeruginosa.
AMR Gene FamilyANT(3'')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniig+wgs, Aeromonas caviaewgs, Aeromonas veroniig, Citrobacter freundiiwgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Serratia marcescenswgs
Resistomes with Sequence VariantsAcinetobacter baumanniig+wgs, Aeromonas caviaewgs, Aeromonas veroniig, Citrobacter freundiiwgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeip, Klebsiella michiganensiswgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs+gi, Pseudomonas monteiliiwgs, Serratia marcescenswgs, Stenotrophomonas maltophiliag
Classification12 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ ANT(3'')-Ia
+ confers_resistance_to_antibiotic spectinomycin [Antibiotic]
+ confers_resistance_to_antibiotic streptomycin [Antibiotic]
Publications

Llanes C, et al. 2006. Clin Microbiol Infect 12(3): 270-278. Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase. (PMID 16451415)

Resistomes

Prevalence of aadA11 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0.18%0%0.03%0%
Aeromonas caviae0%0%0.54%0%
Aeromonas veronii1.82%0%0%0%
Citrobacter freundii0%0%0.19%0%
Enterobacter cloacae0%0%0.32%0%
Enterobacter hormaechei0%0%0.13%0%
Enterobacter kobei0%0.69%0%0%
Klebsiella michiganensis0%0%0.27%0%
Providencia rettgeri0%0%0.64%0%
Pseudomonas aeruginosa0%0%0.6%5.56%
Pseudomonas monteilii0%0%2.38%0%
Serratia marcescens0%0%0.66%0%
Stenotrophomonas maltophilia1.12%0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 450


>gb|AAV32840.1|+|aadA11 [Pseudomonas aeruginosa]
MSNAVPAEISVQLSLALNAIERHLESTLLAVHLYGSALDGGLKPYSDIDLLVTVAAQLDETVRQALVVDLLEISASPGQSEALRALEVTI
VVHGDVVPWRYPARRELQFGEWQRKDILAGIFEPATTDVDLAILLTKVRQHSLALAGSAAEDFFNPVPEGDLFKALSDTLKLWNSQPDWE
GDERNVVLTLSRIWYSAATGKIAPKDIVANWAIERLPDQHKPVLLEARQAYLGQGEDCLASRADQLAAFVHFVKHEATKLLGAMPVMSNN
SFKPNPLRGSA


>gb|AY758206.1|+|2744-3589|aadA11 [Pseudomonas aeruginosa]
ATGAGTAACGCAGTACCCGCCGAGATTTCGGTACAGCTATCACTGGCTCTCAACGCCATCGAGCGTCATCTGGAATCAACGTTGCTGGCC
GTGCATTTGTACGGCTCTGCACTGGACGGTGGCCTGAAGCCATACAGTGATATTGATTTGCTGGTTACTGTGGCTGCACAGCTCGATGAG
ACTGTCCGACAAGCCCTGGTCGTAGATCTCTTGGAAATTTCTGCCTCCCCTGGCCAAAGTGAGGCTCTCCGCGCCTTGGAAGTTACCATC
GTCGTGCATGGTGATGTTGTCCCTTGGCGTTATCCGGCCAGACGGGAACTGCAATTCGGGGAGTGGCAGCGTAAGGACATTCTTGCGGGC
ATCTTCGAGCCCGCCACAACCGATGTTGATCTGGCTATTCTGCTAACTAAAGTAAGGCAGCATAGCCTTGCATTGGCAGGTTCGGCCGCA
GAGGATTTCTTTAACCCAGTTCCGGAAGGCGATCTATTCAAGGCATTGAGCGACACTCTGAAACTATGGAATTCGCAGCCGGATTGGGAA
GGCGATGAGCGGAATGTAGTGCTTACCTTGTCTCGCATTTGGTACAGCGCAGCAACCGGCAAGATCGCACCGAAGGATATCGTTGCCAAC
TGGGCAATTGAGCGTCTGCCAGATCAACATAAGCCCGTACTGCTTGAAGCCCGGCAGGCTTATCTTGGACAAGGAGAAGATTGCTTGGCC
TCACGCGCGGATCAGTTGGCGGCGTTCGTTCACTTCGTGAAACATGAAGCCACTAAATTGCTTGGTGCCATGCCAGTGATGTCTAACAAT
TCATTCAAGCCGAACCCGCTTCGCGGGTCGGCTTAA