Mycobacterium tuberculosis whib7 mutation conferring resistance to streptomycin

Accession ARO:3004968
Synonym(s)whmC
CARD Short NameMtub_whib7_STR
DefinitionMutations in whib7 that can contribute to or confer resistance to streptomycin.
AMR Gene Familystreptomycin resistant whib7
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic target alteration
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic streptomycin [Antibiotic]
+ streptomycin resistant whib7 [AMR Gene Family]
Publications

Reeves AZ, et al. 2013. Antimicrob Agents Chemother 57(4):1857-65 Aminoglycoside cross-resistance in Mycobacterium tuberculosis due to mutations in the 5' untranslated region of whiB7. (PMID 23380727)

Resistomes

Prevalence of Mycobacterium tuberculosis whib7 mutation conferring resistance to streptomycin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 125

Legend:

  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:

PMID in progress (TB): T57G A116G

ReSeqTB:

High ConfidenceA116G T57G

>gb|CCP46011.1|-|Mycobacterium tuberculosis whib7 mutation conferring resistance to streptomycin [Mycobacterium tuberculosis H37Rv]
MSVLTVPRQTPRQRLPVLPCHVGDPDLWFADTPAGLEVAKTLCVSCPIRRQCLAAALQRA
EPWGVWGGEIFDQGSIVSHKRPRGRPRKDAVA



>gb|AL123456.3|-|3568401-3568679|Mycobacterium tuberculosis whib7 mutation conferring resistance to streptomycin [Mycobacterium tuberculosis H37Rv]
GTGTCGGTACTGACAGTCCCCAGACAGACCCCCAGACAAAGATTGCCGGTTTTGCCGTGCCACGTCGGTGATCCCGATCTGTGGTTCGCC
GATACCCCGGCCGGTCTCGAGGTAGCCAAGACACTGTGTGTGAGCTGCCCGATCAGGCGGCAGTGCTTGGCCGCGGCGCTTCAGCGGGCT
GAACCCTGGGGCGTTTGGGGTGGTGAGATATTCGACCAAGGCTCGATCGTGAGTCACAAGCGTCCGCGCGGACGTCCGCGCAAGGATGCT
GTTGCATAG