| Accession | ARO:3002659 |
| Synonym(s) | sph str |
| CARD Short Name | APH(6)-Ic |
| Definition | APH(6)-Ic is a transposon-encoded aminoglycoside phosphotransferase in S. enterica, P. aeruginosa and E. coli. |
| AMR Gene Family | APH(6) |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter lwoffiiwgs, Burkholderia multivoranswgs, Enterobacter hormaecheiwgs, Escherichia coliwgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosag+wgs, Pseudomonas putidawgs, Salmonella entericap+wgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Acinetobacter lwoffiiwgs, Aeromonas caviaewgs, Burkholderia multivoranswgs, Enterobacter hormaecheiwgs, Escherichia coliwgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosag+wgs, Pseudomonas putidawgs, Salmonella entericap+wgs, Shigella sonneiwgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + phosphorylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside phosphotransferase (APH) + aminoglycoside antibiotic [Drug Class] + APH(6) [AMR Gene Family] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Mazodier P, et al. 1985. Nucleic Acids Res 13(1): 195-205. Completion of the nucleotide sequence of the central region of Tn5 confirms the presence of three resistance genes. (PMID 3889831) Steiniger-White M, et al. 2004. Curr Opin Struct Biol 14(1): 50-57. Structure/function insights into Tn5 transposition. (PMID 15102449) |
Prevalence of APH(6)-Ic among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter lwoffii | 0% | 0% | 2.63% | 0% |
| Aeromonas caviae | 0% | 0% | 0.54% | 0% |
| Burkholderia multivorans | 0% | 0% | 0.24% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.04% | 0% |
| Escherichia coli | 0% | 0% | 0.3% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.03% | 0% |
| Pseudomonas aeruginosa | 0.31% | 0% | 0.27% | 0% |
| Pseudomonas putida | 0% | 0% | 0.53% | 0% |
| Salmonella enterica | 0% | 0.33% | 0.54% | 0% |
| Shigella sonnei | 0% | 0% | 0.15% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500