| Accession | ARO:3002704 |
| CARD Short Name | fexA |
| Definition | fexA is a plasmid-encoded chloramphenicol exporter that is found in Mammaliicoccus lentus. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Staphylococcus aureusg+p+wgs |
| Resistomes with Sequence Variants | Bacillus cereuswgs, Campylobacter colig+wgs+gi, Campylobacter jejunig+p+wgs+gi, Clostridium perfringensp+wgs, Enterococcus faecalisg+p+wgs+gi, Enterococcus faeciumg+p+wgs, Enterococcus hiraeg+p+wgs, Escherichia coliwgs, Klebsiella quasipneumoniaep, Lactococcus garvieaep+wgs, Listeria innocuag, Listeria monocytogeneswgs, Staphylococcus arlettaeg+p+wgs, Staphylococcus aureusg+p+wgs+gi, Staphylococcus epidermidiswgs, Staphylococcus equorumg, Staphylococcus haemolyticuswgs, Staphylococcus saprophyticusg+p+wgs, Staphylococcus simulanswgs, Streptococcus gallolyticuswgs, Streptococcus suiswgs |
| Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + phenicol antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] |
| Parent Term(s) | 3 ontology terms | Show + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic florfenicol [Antibiotic] |
| Publications | Kehrenberg C and Schwarz S. 2004. Antimicrob Agents Chemother 48(2): 615-618. fexA, a novel Staphylococcus lentus gene encoding resistance to florfenicol and chloramphenicol. (PMID 14742219) |
Prevalence of fexA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Bacillus cereus | 0% | 0% | 0.1% | 0% |
| Campylobacter coli | 13.04% | 0% | 0.88% | 20% |
| Campylobacter jejuni | 3.16% | 0.99% | 0.23% | 61.54% |
| Clostridium perfringens | 0% | 1.93% | 0.49% | 0% |
| Enterococcus faecalis | 13.18% | 15.02% | 3.98% | 16.67% |
| Enterococcus faecium | 2.87% | 0.52% | 1.97% | 0% |
| Enterococcus hirae | 7.69% | 2.38% | 5.56% | 0% |
| Escherichia coli | 0% | 0% | 0.01% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 0% | 0% |
| Lactococcus garvieae | 0% | 8.33% | 2.22% | 0% |
| Listeria innocua | 17.65% | 0% | 0% | 0% |
| Listeria monocytogenes | 0% | 0% | 0.17% | 0% |
| Staphylococcus arlettae | 16.67% | 8.33% | 2.5% | 0% |
| Staphylococcus aureus | 2.36% | 0.41% | 1.89% | 1.72% |
| Staphylococcus epidermidis | 0% | 0% | 1.67% | 0% |
| Staphylococcus equorum | 8.33% | 0% | 0% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 0.22% | 0% |
| Staphylococcus saprophyticus | 5.88% | 2.7% | 0.7% | 0% |
| Staphylococcus simulans | 0% | 0% | 3.39% | 0% |
| Streptococcus gallolyticus | 0% | 0% | 4.55% | 0% |
| Streptococcus suis | 0% | 0% | 0.16% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500