fexA

Accession ARO:3002704
CARD Short NamefexA
DefinitionfexA is a plasmid-encoded chloramphenicol exporter that is found in Mammaliicoccus lentus.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classphenicol antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesStaphylococcus aureusg+p+wgs
Resistomes with Sequence VariantsBacillus cereuswgs, Campylobacter colig+wgs+gi, Campylobacter jejunig+p+wgs+gi, Clostridium perfringensp+wgs, Enterococcus faecalisg+p+wgs+gi, Enterococcus faeciumg+p+wgs, Enterococcus hiraeg+p+wgs, Escherichia coliwgs, Klebsiella quasipneumoniaep, Lactococcus garvieaep+wgs, Listeria innocuag, Listeria monocytogeneswgs, Staphylococcus arlettaeg+p+wgs, Staphylococcus aureusg+p+wgs+gi, Staphylococcus epidermidiswgs, Staphylococcus equorumg, Staphylococcus haemolyticuswgs, Staphylococcus saprophyticusg+p+wgs, Staphylococcus simulanswgs, Streptococcus gallolyticuswgs, Streptococcus suiswgs
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic florfenicol [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Kehrenberg C and Schwarz S. 2004. Antimicrob Agents Chemother 48(2): 615-618. fexA, a novel Staphylococcus lentus gene encoding resistance to florfenicol and chloramphenicol. (PMID 14742219)

Resistomes

Prevalence of fexA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Bacillus cereus0%0%0.1%0%
Campylobacter coli13.04%0%0.88%20%
Campylobacter jejuni3.16%0.99%0.23%61.54%
Clostridium perfringens0%1.93%0.49%0%
Enterococcus faecalis13.18%15.02%3.98%16.67%
Enterococcus faecium2.87%0.52%1.97%0%
Enterococcus hirae7.69%2.38%5.56%0%
Escherichia coli0%0%0.01%0%
Klebsiella quasipneumoniae0%0.21%0%0%
Lactococcus garvieae0%8.33%2.22%0%
Listeria innocua17.65%0%0%0%
Listeria monocytogenes0%0%0.17%0%
Staphylococcus arlettae16.67%8.33%2.5%0%
Staphylococcus aureus2.36%0.41%1.89%1.72%
Staphylococcus epidermidis0%0%1.67%0%
Staphylococcus equorum8.33%0%0%0%
Staphylococcus haemolyticus0%0%0.22%0%
Staphylococcus saprophyticus5.88%2.7%0.7%0%
Staphylococcus simulans0%0%3.39%0%
Streptococcus gallolyticus0%0%4.55%0%
Streptococcus suis0%0%0.16%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|CAD70268.1|+|fexA [Mammaliicoccus lentus]
MKKDSKSKEMIQSEKRGSTRLLMMVLSLSVLVGAITADLVNPVLPLISKDLEASKSQVSWIVSGIALVLAIGVPIYGRISDFFELRKLYI
FAIMILASGSLLCAIAPNLPLLVLGRMVQGAGMSAIPVLSIIAISKVFPQGKRGGALGIIAGSIGVGTAAGPIFGGVVGQYLGWNALFWF
TFLLAIMIVIGAYYALPTIKPAESVGSNKNFDFIGGLFLGLTVGLLLFGITQGETSGFSSFSSLTSLIGSVVALVGFIWRIVTAENPFVP
PVLFNNKDYVNTVIIAFFSMFAYFAVLVFVPLLVVEVNGLSSGQAGMILLPGGVAVAILSPFVGRLSDRFGDKRLIITGMTLMGLSTLFL
STYASGASPLLVSVGVLGVGIAFAFTNSPANNAAVSALDADKVGVGMGIFQGALYLGAGTGAGMIGALLSARRDATEPINPLYILDAMSY
SDAFLAATGAILIALIAGLGLKKRG


>gb|AJ549214.1|+|177-1604|fexA [Mammaliicoccus lentus]
ATGAAAAAGGATAGTAAATCTAAAGAAATGATTCAATCTGAAAAAAGGGGTTCTACTAGGCTTTTAATGATGGTACTCTCCCTATCTGTA
CTTGTAGGTGCAATTACGGCTGATTTAGTCAATCCCGTACTTCCACTAATAAGCAAAGATTTAGAAGCTTCGAAATCTCAAGTGAGTTGG
ATAGTTAGTGGTATTGCACTTGTTCTTGCGATTGGAGTTCCGATTTATGGTCGAATCTCAGACTTTTTTGAGTTACGAAAGCTATATATC
TTTGCCATTATGATTCTGGCAAGTGGTAGTCTTTTATGTGCAATTGCCCCGAACCTCCCATTGTTGGTTTTGGGAAGAATGGTTCAGGGT
GCTGGGATGTCCGCAATTCCAGTTCTATCAATCATTGCAATTTCGAAGGTTTTCCCACAAGGAAAACGTGGGGGAGCTTTGGGAATTATC
GCAGGAAGTATTGGTGTTGGAACTGCTGCTGGTCCAATATTTGGTGGAGTAGTTGGTCAATATTTAGGGTGGAATGCCTTGTTTTGGTTC
ACATTTTTGTTAGCCATTATGATTGTTATTGGTGCCTACTACGCGTTACCGACAATTAAACCGGCAGAATCCGTAGGAAGCAATAAGAAC
TTTGATTTCATTGGTGGTTTATTCCTCGGCCTCACAGTAGGATTACTCCTTTTTGGCATCACTCAAGGAGAAACTTCTGGTTTTTCTTCG
TTCTCATCGTTAACTAGCCTAATTGGTTCTGTTGTAGCTTTGGTGGGATTTATTTGGAGAATTGTTACCGCAGAAAATCCATTTGTACCA
CCTGTCCTGTTCAATAACAAGGATTATGTCAATACGGTCATAATTGCATTTTTTTCGATGTTTGCTTATTTCGCTGTTCTTGTGTTCGTC
CCATTACTAGTCGTTGAGGTGAATGGACTCTCTTCTGGACAGGCTGGAATGATATTGTTGCCAGGTGGTGTGGCTGTTGCAATCTTATCT
CCCTTCGTTGGCCGTCTTTCTGATCGATTTGGGGATAAACGTCTGATAATTACTGGGATGACTCTGATGGGGCTGTCTACCTTATTCTTG
TCCACCTATGCATCTGGTGCTTCACCTCTGTTAGTTTCCGTGGGGGTCCTCGGAGTAGGGATTGCTTTTGCATTCACGAATTCTCCCGCA
AATAACGCCGCAGTAAGTGCACTCGATGCAGACAAGGTTGGTGTCGGAATGGGGATTTTCCAAGGTGCTTTGTACCTTGGAGCAGGAACT
GGAGCAGGTATGATTGGAGCATTATTATCCGCTCGACGTGATGCTACTGAGCCGATAAATCCATTATATATATTGGACGCTATGTCCTAC
TCAGATGCGTTCCTTGCAGCTACAGGGGCAATACTCATTGCCTTAATAGCTGGATTAGGTTTAAAAAAGCGTGGGTAA