Accession ARO:3003963
DefinitionThe Flo transporters can be plasmid- or chromosome-encoded. flo is an important determinant of florfenicol resistance in animal isolates of E. coli but is also found in human pathogens (e.g. Salmonella enterica and V. cholerae).
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classphenicol antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic florfenicol [Antibiotic]
2 ontology terms | Show

Poole K. 2005. J Antimicrob Chemother 56(1): 20-51. Efflux-mediated antimicrobial resistance. (PMID 15914491)

Keyes K, et al. 2000. Antimicrob. Agents Chemother. 44(2):421-4 Detection of florfenicol resistance genes in Escherichia coli isolated from sick chickens. (PMID 10639375)

White DG, et al. 2000. J Clin Microbiol 38(12): 4593-4598. Characterization of chloramphenicol and florfenicol resistance in Escherichia coli associated with bovine diarrhea. (PMID 11101601)