tiamulin [Antibiotic]

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Accession ARO:3000671
DefinitionTiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation.
Drug Classpleuromutilin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
20 ontology terms | Show
+ cipA confers_resistance_to_antibiotic
+ cfrA confers_resistance_to_antibiotic
+ clbA confers_resistance_to_antibiotic
+ clbB confers_resistance_to_antibiotic
+ clbC confers_resistance_to_antibiotic
+ clcD confers_resistance_to_antibiotic
+ salA confers_resistance_to_antibiotic
+ salB confers_resistance_to_antibiotic
+ salC confers_resistance_to_antibiotic
+ salD confers_resistance_to_antibiotic
+ salE confers_resistance_to_antibiotic
+ Thermus thermophilus 23s rRNA conferring resistance to pleuromutilin antibiotics confers_resistance_to_antibiotic
+ Thermus thermophilus uL3 mutations conferring resistance to pleuromutilin antibiotics confers_resistance_to_antibiotic
+ lsaD confers_resistance_to_antibiotic
+ vga(E) Staphylococcus cohnii confers_resistance_to_antibiotic
+ vgaC confers_resistance_to_antibiotic
+ vgaE confers_resistance_to_antibiotic
+ cfrE confers_resistance_to_antibiotic
+ vmlR confers_resistance_to_antibiotic
+ Neobacillus vireti vmlR2 confers_resistance_to_antibiotic

Novak R and Shlaes DM. 2010. Curr Opin Investig Drugs 11(2): 182-191. The pleuromutilin antibiotics: a new class for human use. (PMID 20112168)

Schlunzen F, et al. 2004. Mol Microbiol 54(5): 1287-1294. Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin. (PMID 15554968)

Gurel G, et al. 2009. J Mol Biol 389(1): 146-156. U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. (PMID 19362093)

Poulsen SM, et al. 2001. Mol Microbiol 41(5): 1091-1099. The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome. (PMID 11555289)