| Accession | ARO:3002814 |
| CARD Short Name | clbA |
| Definition | clbA is a plasmid-encoded cfr gene found in Bacillus velezensis (Bacillus amyloliquefaciens subsp. plantarum). |
| AMR Gene Family | Cfr 23S ribosomal RNA methyltransferase |
| Drug Class | oxazolidinone antibiotic, phenicol antibiotic, streptogramin antibiotic, lincosamide antibiotic, pleuromutilin antibiotic, streptogramin A antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Perfect Matches | Bacillus amyloliquefaciensg+wgs, Bacillus velezensisg+wgs |
| Resistomes with Sequence Variants | Bacillus amyloliquefaciensg+wgs+gi, Bacillus subtilisg, Bacillus velezensisg+wgs+gi |
| Classification | 17 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + antibiotic target modifying enzyme + ribosomal alteration conferring antibiotic resistance + rRNA methyltransferase conferring antibiotic resistance + 23S ribosomal RNA methyltransferase + antibiotic molecule + oxazolidinone antibiotic [Drug Class] + phenicol antibiotic [Drug Class] + S-adenosylmethionine (SAM) superfamily + streptogramin antibiotic [Drug Class] + lincosamide antibiotic [Drug Class] + pleuromutilin antibiotic [Drug Class] + streptogramin A antibiotic [Drug Class] + Cfr 23S ribosomal RNA methyltransferase [AMR Gene Family] |
| Parent Term(s) | 11 ontology terms | Show + Cfr Group + confers_resistance_to_antibiotic clindamycin [Antibiotic] + confers_resistance_to_antibiotic lincomycin [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic tiamulin [Antibiotic] + confers_resistance_to_antibiotic dalfopristin [Antibiotic] + confers_resistance_to_antibiotic griseoviridin [Antibiotic] + confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic] + confers_resistance_to_antibiotic madumycin II [Antibiotic] + confers_resistance_to_antibiotic azidamfenicol [Antibiotic] + confers_resistance_to_antibiotic thiamphenicol [Antibiotic] |
| Publications | Hansen LH, et al. 2012. Antimicrob Agents Chemother 56(7): 3563-3567. The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene. (PMID 22547628) |
Prevalence of clbA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Bacillus amyloliquefaciens | 85.71% | 0% | 73.03% | 66.67% |
| Bacillus subtilis | 1.43% | 0% | 0% | 0% |
| Bacillus velezensis | 80.6% | 0% | 62.64% | 52.17% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 600