| Accession | ARO:3007646 |
| Definition | vmlR2 is an ABC-F ATPase ribosomal protection protein from Neobacillus vireti (formerly known as Bacillus vireti). This representative of the ARE2 subfamily has an unusually long linker domain. Confers resistance to some lincosamide and nucleoside antibiotics. |
| AMR Gene Family | Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins |
| Drug Class | nucleoside antibiotic, streptogramin antibiotic, pleuromutilin antibiotic, streptogramin A antibiotic, lincosamide antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target protection [Resistance Mechanism] + antibiotic target protection protein + nucleoside antibiotic [Drug Class] + streptogramin antibiotic [Drug Class] + ABC-F ATP-binding cassette ribosomal protection protein + pleuromutilin antibiotic [Drug Class] + aminonucleoside antibiotic + antibiotic without defined classification + streptogramin A antibiotic [Drug Class] + lincosamide antibiotic [Drug Class] |
| Parent Term(s) | 7 ontology terms | Show + confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic] + confers_resistance_to_antibiotic tiamulin [Antibiotic] + confers_resistance_to_antibiotic retapamulin [Antibiotic] + Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins [AMR Gene Family] + confers_resistance_to_antibiotic iboxamycin [Antibiotic] + confers_resistance_to_antibiotic hygromycin A [Antibiotic] + confers_resistance_to_antibiotic A201A [Antibiotic] |
| Publications | Obana N, et al. 2023. Nucleic Acids Res 51(9):4536-4554 Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR. (PMID 36951104) |