| Accession | ARO:3007646 |
| Definition | vmlR2 is an ABC-F ATPase ribosomal protection protein from Neobacillus vireti (formerly known as Bacillus vireti). This representative of the ARE2 subfamily has an unusually long linker domain. Confers resistance to some lincosamide and nucleoside antibiotics. |
| AMR Gene Family | Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins |
| Drug Class | nucleoside antibiotic, streptogramin antibiotic, pleuromutilin antibiotic, streptogramin A antibiotic, lincosamide antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + determinant of antibiotic resistance + antibiotic target protection [Resistance Mechanism] + nucleoside antibiotic [Drug Class] + streptogramin antibiotic [Drug Class] + antibiotic target protection protein + antibiotic without defined classification + pleuromutilin antibiotic [Drug Class] + streptogramin A antibiotic [Drug Class] + ABC-F ATP-binding cassette ribosomal protection protein + lincosamide antibiotic [Drug Class] + aminonucleoside antibiotic |
| Parent Term(s) | 7 ontology terms | Show + confers_resistance_to_antibiotic iboxamycin [Antibiotic] + confers_resistance_to_antibiotic A201A [Antibiotic] + confers_resistance_to_antibiotic hygromycin A [Antibiotic] + confers_resistance_to_antibiotic retapamulin [Antibiotic] + confers_resistance_to_antibiotic tiamulin [Antibiotic] + confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic] + Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins [AMR Gene Family] |
| Publications | Obana N, et al. 2023. Nucleic Acids Res 51(9):4536-4554 Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR. (PMID 36951104) |