| Accession | ARO:3003749 |
| Synonym(s) | sal(A) |
| CARD Short Name | salA |
| Definition | salA is an ABC-F subfamily protein gene isolated from the chromosome of Mammaliicoccus sciuri conferring resistance to lincosamides and streptogramins. |
| AMR Gene Family | sal-type ABC-F protein |
| Drug Class | streptogramin antibiotic, pleuromutilin antibiotic, streptogramin A antibiotic, lincosamide antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic target protection [Resistance Mechanism] + determinant of antibiotic resistance + streptogramin antibiotic [Drug Class] + antibiotic target protection protein + pleuromutilin antibiotic [Drug Class] + streptogramin A antibiotic [Drug Class] + ABC-F ATP-binding cassette ribosomal protection protein + lincosamide antibiotic [Drug Class] |
| Parent Term(s) | 6 ontology terms | Show + confers_resistance_to_antibiotic retapamulin [Antibiotic] + confers_resistance_to_antibiotic tiamulin [Antibiotic] + confers_resistance_to_antibiotic lincomycin [Antibiotic] + confers_resistance_to_antibiotic clindamycin [Antibiotic] + sal-type ABC-F protein [AMR Gene Family] + confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic] |
| Publications | Hot C, et al. 2014. Antimicrob. Agents Chemother. 58(6):3335-41 Characterization of sal(A), a novel gene responsible for lincosamide and streptogramin A resistance in Staphylococcus sciuri. (PMID 24687494) Wendlandt S, et al. 2015. Vet. Microbiol. 177(3-4):353-8 Identification of ABC transporter genes conferring combined pleuromutilin-lincosamide-streptogramin A resistance in bovine methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci. (PMID 25891423) |
Prevalence of salA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 1100