LnuH

Accession ARO:3004600
CARD Short NameLnuH
DefinitionLnuH is a lincosamide nucleotidyltransferase transferase.
AMR Gene Familylincosamide nucleotidyltransferase (LNU)
Drug Classlincosamide antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesRiemerella anatipestiferg+wgs
Resistomes with Sequence VariantsElizabethkingia anophelisg+wgs, Glaesserella parasuiswgs, Myroides odoratimimuswgs, Myroides phaeuswgs, Riemerella anatipestiferg+wgs
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ lincosamide nucleotidyltransferase (LNU) [AMR Gene Family]
+ confers_resistance_to_antibiotic lincomycin [Antibiotic]
+ confers_resistance_to_antibiotic clindamycin [Antibiotic]
Publications

Luo HY, et al. 2018. Int J Antimicrob Agents 51(1):136-139 A novel resistance gene, lnu(H), conferring resistance to lincosamides in Riemerella anatipestifer CH-2. (PMID 28843817)

Resistomes

Prevalence of LnuH among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Elizabethkingia anophelis3.85%0%6.19%0%
Glaesserella parasuis0%0%0.51%0%
Myroides odoratimimus0%0%7.14%0%
Myroides phaeus0%0%100%0%
Riemerella anatipestifer33.33%0%13.19%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|WP_051021433.1|-|LnuH [Riemerella anatipestifer RA-CH-2]
MTQLQMINKTKSIAQQDENVSAVFMYGSFTKSEGDKYSDIEFYIFLKNKENFSSEKWVNQIHPVALYFTNEYGSEVAIFENMVRGEFHFL
KTEEIEIIKSWDGIVAFSDFDQMNLIDKDGHLTKTLNQIKTKSPERITNENILWLSQSLLNVILTTSNLIKREEFAHAHHSLSNVQKYLL
WLIRARTNKTQHWESPTKSLEKDIDTTWYFAYKTVTSDLNPKNIILAFENSLNLSEKLFDELNIEPKMKEILHEIRKNYR


>gb|NC_020125.1|-|1861441-1862223|LnuH [Riemerella anatipestifer RA-CH-2]
ATGACGCAGTTACAAATGATTAACAAAACAAAATCTATAGCTCAACAAGACGAAAATGTTTCCGCTGTTTTTATGTATGGTTCATTTACT
AAAAGCGAAGGAGATAAATATTCTGATATCGAATTTTACATCTTTTTAAAAAATAAAGAAAATTTCTCGTCGGAAAAATGGGTAAATCAA
ATTCATCCTGTGGCATTATATTTTACAAATGAATATGGAAGCGAAGTTGCTATTTTTGAGAATATGGTCAGAGGCGAATTTCATTTTTTA
AAAACGGAGGAAATTGAAATTATCAAATCTTGGGACGGAATTGTTGCATTTAGCGATTTTGACCAAATGAACCTAATCGACAAAGACGGA
CATTTAACGAAAACACTAAATCAAATCAAAACGAAATCGCCCGAAAGAATAACAAATGAAAACATCTTGTGGTTAAGTCAATCATTACTG
AATGTTATACTGACAACAAGCAACTTAATTAAGCGAGAAGAATTTGCTCATGCTCATCATAGTTTATCAAATGTTCAGAAATATTTGCTT
TGGCTTATTAGAGCAAGAACAAACAAAACCCAACATTGGGAAAGTCCAACTAAAAGTCTTGAAAAGGATATTGATACGACTTGGTATTTT
GCGTATAAAACAGTAACATCGGATTTAAATCCTAAAAATATAATTTTAGCTTTTGAAAACTCATTAAATTTATCGGAAAAACTATTTGAC
GAACTAAATATTGAACCAAAAATGAAAGAAATCCTACATGAAATAAGAAAAAACTACCGCTAA