lmrC

Accession ARO:3002881
Synonym(s)ydaG
DefinitionlmrC is an ABC-F subfamily protein that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD
AMR Gene FamilyABC-F ATP-binding cassette ribosomal protection protein
Drug Classphenicol antibiotic, lincosamide antibiotic, macrolide antibiotic, tetracycline antibiotic, streptogramin antibiotic, oxazolidinone antibiotic, pleuromutilin antibiotic
Resistance Mechanismantibiotic target protection
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class lincosamide antibiotic [Drug Class]
+ ABC-F ATP-binding cassette ribosomal protection protein [AMR Gene Family]
Publications

Florez AB, et al. 2006. FEMS Microbiol Lett 263(1): 21-25. Ubiquity and diversity of multidrug resistance genes in Lactococcus lactis strains isolated between 1936 and 1995. (PMID 16958846)

Resistomes

Prevalence of lmrC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1050


>gb|ABX00624.1|-|lmrC [Streptomyces lincolnensis]
MADASIVCTNLSFSWPDETPVFDGLSFALGAGRCGLVGPNGAGKSTLLRLAVGELTPTAGSITAQGHVGYLPQSLPLIDGTVDEALEIAS
IRAALHAIESGDVDEAHFTTVGDHWDIEERTTIVLDRLGLGDVSLDRPLRSLSGGQVLAIGLAAQLLKRPDVLILDEPTNNLDLAARQRL
YQVVEEWKGALLVVSHDRELLDRVDTIAELQASELRLYGGNFTAYTEAVELEQENVQRAVRGAEQELRRHKREAQAAQERAQRRASNAKR
NKASSGVPRIHAGALQRQAQESAGRAASVHQDRVSQAKAKLDEASQGMREEARLAITLPQTSVPAGRTVLTCHEANVRYGERTLFTGSGV
DLGIRGPERIALLGPNGSGKSTLLKLIAGELEPSSGTVTAPTDRVSYLSQRLDLLDLDASVLDNLRRFAPHLQDGEVRYRLAQFLFRGDR
VHRTAGWLSGGERLRATLACVLSTDPAPQLLLLDEPTNNLDLNSAAQLENALNAFQGAFVVVSHDQAFLRAIGVSRWLRLADGTLEEIAE
ADDAWPHRDK


>gb|EU124663.1|-|32696-34348|lmrC [Streptomyces lincolnensis]
ATGGCTGACGCGAGTATTGTCTGCACCAATCTCTCCTTCTCCTGGCCCGACGAGACGCCGGTCTTCGACGGGTTGTCCTTTGCCCTCGGC
GCCGGCCGTTGCGGCCTCGTGGGCCCCAATGGCGCGGGAAAGTCCACACTGTTGCGGCTCGCCGTAGGGGAACTCACCCCTACCGCAGGC
TCGATCACCGCGCAGGGACATGTCGGGTACCTGCCGCAGTCCCTGCCGCTGATCGACGGCACCGTCGACGAGGCCCTGGAGATCGCCTCC
ATCCGGGCGGCTCTGCATGCCATCGAGTCAGGTGACGTGGACGAGGCGCACTTCACCACTGTGGGCGATCACTGGGACATCGAGGAACGC
ACCACGATCGTCCTGGACCGTCTGGGTCTCGGCGACGTGTCCCTTGACCGCCCGCTTCGCTCCCTCAGCGGCGGCCAGGTCCTCGCCATC
GGCCTGGCCGCGCAGCTCCTGAAGCGACCCGACGTGCTGATCCTCGACGAACCCACCAACAACCTTGACCTGGCCGCCCGGCAGCGGCTC
TACCAGGTCGTCGAAGAGTGGAAGGGGGCCCTCCTCGTCGTCAGCCACGACCGGGAGCTCCTGGACCGCGTAGACACCATCGCCGAGCTG
CAGGCATCCGAACTCCGCCTCTACGGTGGCAACTTCACCGCCTACACGGAAGCCGTCGAGCTGGAACAGGAGAACGTGCAGCGCGCGGTG
CGCGGGGCGGAGCAGGAGTTGCGCCGCCACAAGCGCGAGGCGCAGGCGGCCCAGGAGCGGGCCCAGCGCCGGGCCAGCAACGCCAAGCGC
AACAAGGCTTCGTCGGGGGTGCCCCGTATCCACGCGGGCGCCCTTCAGCGACAGGCTCAGGAATCGGCGGGCCGCGCCGCCTCGGTGCAC
CAGGACCGGGTGTCCCAGGCCAAGGCCAAGCTGGACGAGGCCAGTCAGGGGATGCGTGAGGAAGCGCGCCTGGCGATCACCCTTCCGCAG
ACCTCGGTCCCGGCCGGACGCACCGTGTTGACGTGCCATGAGGCCAATGTCCGGTACGGGGAACGGACGTTGTTCACCGGCTCGGGCGTC
GACCTCGGGATCCGCGGGCCGGAGCGGATCGCGCTGCTCGGGCCCAACGGCTCGGGCAAGTCAACGCTGTTGAAGCTGATCGCCGGCGAG
CTCGAACCCTCCTCGGGGACGGTCACGGCGCCGACGGACCGGGTGTCCTATCTCTCGCAGCGCCTCGATCTGCTCGACTTGGACGCCAGC
GTCCTGGACAACCTGCGCCGTTTCGCCCCGCATCTGCAGGACGGCGAAGTCCGCTACCGCCTGGCGCAGTTCCTCTTCCGCGGCGACCGA
GTTCATCGCACCGCCGGATGGCTCTCCGGCGGTGAGCGGCTGCGCGCGACCCTGGCGTGTGTCCTGTCCACGGACCCTGCCCCTCAGCTG
CTCCTGCTGGACGAGCCGACGAACAACCTCGACCTCAACAGTGCCGCCCAGCTGGAGAACGCGCTCAACGCCTTCCAGGGCGCCTTCGTA
GTCGTCAGCCACGACCAGGCGTTCCTGCGCGCCATCGGTGTCTCGCGCTGGCTGCGCCTGGCGGACGGAACCCTGGAGGAGATCGCGGAG
GCGGACGACGCGTGGCCTCATCGGGATAAGTGA