lsaC

Accession ARO:3003112
DefinitionLsaC is an ABC-F subfamily protein expressed in Streptococcus agalactiae. It confers resistance to lincomycin, clindamycin, dalfopristin, and tiamulin
AMR Gene FamilyABC-F ATP-binding cassette ribosomal protection protein
Drug Classtetracycline antibiotic, macrolide antibiotic, pleuromutilin antibiotic, lincosamide antibiotic, oxazolidinone antibiotic, streptogramin antibiotic, phenicol antibiotic
Resistance Mechanismantibiotic target protection
Classification14 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_drug_class lincosamide antibiotic [Drug Class]
+ confers_resistance_to_drug_class streptogramin antibiotic [Drug Class]
+ confers_resistance_to_antibiotic pleuromutilin [Antibiotic]
+ lsa-type ABC-F protein
Publications

Malbruny B, et al. 2011. Antimicrob Agents Chemother 55(4): 1470-1474. Cross-resistance to lincosamides, streptogramins A, and pleuromutilins due to the lsa(C) gene in Streptococcus agalactiae UCN70. (PMID 21245447)

Resistomes

Prevalence of lsaC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Streptococcus agalactiae0%0%0.1%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 960


>gb|AEA37904.1|+|lsaC [Streptococcus agalactiae]
MSTIKIENLTFSYYGYVKPVFENVSFSFDTNWKTGLIGRNGIGKSTLFKLLLNQEVYKGKISKSVDFIKFPPNLSDTSKLGIELYRELIS
DEEEWKLFRELHLLKVDESLIYRKFETLSKGEQTKILLAILFTREDGFLLIDEPTNHLDMDGRKIVSEYLKNKKGFLLISHDRDFLDGCI
NHIISINRNSIDVQSGNFTSWYENKLMKDQFEISQNEKLRKDIKRLKEAARQSQIWSDKVENTKNGVKVSGVKPDKGHIGHQSAKMMKKS
KNLENRQNKAIEEKQNLLKDIETKESLLLHPLHHHKNPLISVCDLSSYYGKKQILSNISFDIKQGDIVAIYGGNGSGKSTLIKILLGLNH
EYSGDVKLASNLKISYVPQDTSNLTGSLNEYIHKQGVDETLCKTILRKLDFARELFEIDMKNYSDGQKKKVLIAVSLSKSAHIFIWDEPL
NYLDVISRIQIEEIIKEANPTLIFVEHDKSFVEDIANKIIRL


>gb|HM990671|+|5193-6671|lsaC [Streptococcus agalactiae]
ATGTCAACAATTAAAATTGAAAACCTTACTTTCTCATATTATGGCTATGTAAAACCTGTATTTGAAAATGTATCATTTTCATTTGATACG
AACTGGAAAACAGGACTAATAGGAAGAAACGGAATTGGGAAATCAACACTATTTAAGCTGCTTCTAAACCAAGAAGTTTATAAGGGGAAA
ATCAGCAAAAGTGTTGACTTTATTAAATTCCCACCCAATTTAAGTGATACTTCAAAATTAGGGATTGAGTTATATAGAGAACTAATATCA
GATGAGGAAGAATGGAAATTATTTAGAGAACTTCATTTGCTAAAGGTAGATGAGAGTCTTATTTACAGAAAGTTTGAAACGCTTTCTAAA
GGAGAACAAACAAAAATCCTTTTAGCTATTTTGTTTACAAGAGAAGATGGTTTTTTACTTATAGATGAACCAACAAACCATTTAGATATG
GACGGAAGAAAAATTGTCAGTGAATATCTGAAAAATAAAAAAGGTTTTTTGCTTATATCACATGATAGAGATTTTTTAGATGGTTGTATC
AATCATATTATTTCTATTAACAGGAATTCTATTGATGTCCAATCAGGAAATTTTACATCGTGGTATGAAAATAAATTGATGAAAGACCAA
TTTGAGATTAGTCAAAATGAGAAATTAAGAAAAGATATTAAACGATTAAAAGAAGCTGCAAGACAAAGTCAAATTTGGTCTGATAAAGTT
GAAAATACTAAAAACGGCGTGAAAGTATCAGGTGTAAAACCAGACAAGGGGCATATAGGTCATCAGTCAGCTAAGATGATGAAAAAATCT
AAGAATTTGGAGAATAGACAAAATAAGGCAATAGAAGAAAAACAGAATTTACTAAAAGATATTGAAACAAAGGAAAGTCTATTATTGCAT
CCGTTACATCACCACAAAAATCCTCTAATATCAGTTTGCGATTTATCATCATATTATGGAAAAAAGCAGATATTAAGTAATATAAGTTTT
GATATAAAGCAAGGTGATATAGTGGCTATATATGGGGGTAATGGTAGCGGAAAATCAACCTTGATTAAAATTTTATTAGGTCTAAATCAC
GAGTATTCAGGTGATGTAAAATTAGCAAGTAATTTAAAAATATCATATGTTCCTCAAGATACATCCAATTTAACAGGTAGCCTAAACGAG
TATATTCATAAGCAAGGTGTTGATGAAACATTGTGCAAAACAATTCTTAGAAAATTAGATTTTGCAAGAGAATTATTTGAAATAGATATG
AAGAACTATAGCGATGGACAAAAAAAGAAAGTTTTAATTGCTGTAAGTTTGTCAAAGTCAGCTCATATATTTATTTGGGACGAACCACTG
AATTATTTAGATGTAATATCAAGAATACAGATTGAGGAAATTATAAAAGAAGCAAATCCTACACTCATATTTGTGGAACACGATAAGAGT
TTTGTAGAAGATATAGCGAATAAAATAATACGATTATAA