| Accession | ARO:3002837 |
| Synonym(s) | linC |
| CARD Short Name | lnuC |
| Definition | lnuC is a transposon-mediated nucleotidyltransferase found in Streptococcus agalactiae. |
| AMR Gene Family | lincosamide nucleotidyltransferase (LNU) |
| Drug Class | lincosamide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Anaerostipes hadruswgs, Brachyspira pilosicolig+wgs, Campylobacter coliwgs, Campylobacter jejunig+wgs+gi, Clostridium perfringenswgs, Enterocloster clostridioformiswgs, Enterococcus faecalisp+wgs, Enterococcus faeciumwgs, Escherichia coliwgs, Eubacterium maltosivoransg, Faecalibacterium prausnitziiwgs, Fusobacterium nucleatumg, Glaesserella parasuisg+wgs, Lactobacillus crispatusg+wgs, Lactobacillus johnsoniig+wgs, Ligilactobacillus animalisg+wgs, Megasphaera stantoniig+wgs, Mobiluncus mulieriswgs, Streptococcus agalactiaeg+wgs, Streptococcus dysgalactiaewgs, Streptococcus equinusgi, Streptococcus gallolyticuswgs, Streptococcus lutetiensisg+wgs, Streptococcus mitisg+wgs, Streptococcus pasteurianusg+wgs+gi, Streptococcus suisg+wgs, Streptococcus uberiswgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + determinant of antibiotic resistance + antibiotic inactivation enzyme + lincosamide antibiotic [Drug Class] + nucleotidylation of antibiotic conferring resistance |
| Parent Term(s) | 2 ontology terms | Show + lincosamide nucleotidyltransferase (LNU) [AMR Gene Family] + confers_resistance_to_antibiotic lincomycin [Antibiotic] |
| Publications | Achard A, et al. 2005. Antimicrob Agents Chemother 49(7): 2716-2719. New lnu(C) gene conferring resistance to lincomycin by nucleotidylation in Streptococcus agalactiae UCN36. (PMID 15980341) |
Prevalence of lnuC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Anaerostipes hadrus | 0% | 0% | 3.45% | 0% |
| Brachyspira pilosicoli | 25% | 0% | 4.55% | 0% |
| Campylobacter coli | 0% | 0% | 1.23% | 0% |
| Campylobacter jejuni | 1.05% | 0% | 0.5% | 15.38% |
| Clostridium perfringens | 0% | 0% | 0.49% | 0% |
| Enterocloster clostridioformis | 0% | 0% | 2.33% | 0% |
| Enterococcus faecalis | 0% | 0.25% | 0.04% | 0% |
| Enterococcus faecium | 0% | 0% | 0.14% | 0% |
| Escherichia coli | 0% | 0% | 0.04% | 0% |
| Eubacterium maltosivorans | 100% | 0% | 0% | 0% |
| Faecalibacterium prausnitzii | 0% | 0% | 1.94% | 0% |
| Fusobacterium nucleatum | 8.33% | 0% | 0% | 0% |
| Glaesserella parasuis | 3.85% | 0% | 2.56% | 0% |
| Lactobacillus crispatus | 8% | 0% | 1.33% | 0% |
| Lactobacillus johnsonii | 16.67% | 0% | 3.45% | 0% |
| Ligilactobacillus animalis | 100% | 0% | 33.33% | 0% |
| Megasphaera stantonii | 100% | 0% | 25% | 0% |
| Mobiluncus mulieris | 0% | 0% | 5.88% | 0% |
| Streptococcus agalactiae | 0.93% | 0% | 1.48% | 0% |
| Streptococcus dysgalactiae | 0% | 0% | 1.87% | 0% |
| Streptococcus equinus | 0% | 0% | 0% | 33.33% |
| Streptococcus gallolyticus | 0% | 0% | 6.82% | 0% |
| Streptococcus lutetiensis | 14.29% | 0% | 18.37% | 0% |
| Streptococcus mitis | 11.11% | 0% | 1.01% | 0% |
| Streptococcus pasteurianus | 25% | 0% | 35% | 16.67% |
| Streptococcus suis | 1.6% | 0% | 0.63% | 0% |
| Streptococcus uberis | 0% | 0% | 6.25% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300